Action potential changes associ- ated with impairment of functional properties of sodium channels in hippocampal neurons induced by melamine. Toxicol Lett 2010; 198(2): 171-176.Yang JJ, Yang Z, Zhang T. Action potential changes associated with impairment of func- tional properties of sodium ...
J. Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. J. Neurosci. 27, 13552–13566 (2007). CAS PubMed PubMed Central Google Scholar Hu, W. et al. Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation. ...
Molecular Studies of Alpha-Scorpion Toxin Interactions with Voltage-gated Sodium Channels Voltage-gated sodium channels are responsible for initiation and propagation of the action potential in vertebrate nerve and muscle. They are also the molecular targets for a large number of paralytic neurotoxins. ...
Prolongation of Action Potential Duration and QT Interval During Epilepsy Linked to Increased Contribution of Neuronal Sodium Channels to Cardiac Late Na+ Current: Potential Mechanism for Sudden Death in Epilepsy... BN Smith - 《Epilepsy Currents》 被引量: 0发表: 2016年 Cellular consequences of HERG...
Voltage-gated sodium channels (NaV-α) are transmembrane proteins crucial for action potential generation, duration, and propagation in excitable cells. They contain 4 homologous domains, each containing 6 transmembrane segments. The pore-forming NaV-α associates with 2 or more NaV-β subunits, whic...
Voltage-gated sodium channels (Navs) play essential roles in excitable tissues, with their activation and opening resulting in the initial phase of the action potential. The cycling of Navs through open, closed and inactivated states, and their closely choreographed relationships with the activities ...
opensthepore Mechanicallygated(stretchreceptor)–Physicaltorsionordeformationopensthechannelpore SodiumChannels-Function Playacentralroleinthetransmissionofactionpotentialsalonganerve Canbeindifferentfunctionalstates(3) -Arestingstatewhenitcanrespondtoadepolarizingvoltagechanges -Activated,whenitallowsflowofNa+ionsthrough...
Neurotoxins as allosteric modifiers of action potential sodium channels : W. A. Catterall Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195, U.S.A.doi:10.1016/0041-0101(79)90024-2NoneToxicon
Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an increa
24.4.5 Acid-sensing Ion Channels Acid-sensing ion channels (ASICs) are members of the DEG/ENaC family of ion channels that contribute to the detection of pH and mechanical stimuli via entry (mainly) of sodium ions. Other voltage-gated sodium channels and potassium channels are discussed in Sec...