B cells and monocytes in AML bone marrow (n = 44 patients) compared to bone marrow from unaffected donors (n = 6 donors) (top) and representative flow cytometry histograms (bottom);Pvalues are from Welch’s unpairedt-test. **P = 0.0048 (classic memory B cells) and 0.0094 ...
Conclusions :Globally expressed dSNRNP200 is essential for Drosophila photoreceptor function. Modeling RP33 mutations in the fly recapitulated many aspects of the human disease, which will allow for a molecular dissection of disease mechanisms and genetic and pharmacological screens for potential treatments...
p.I698, and p.R1779) were absolutely conserved, whereas the p.A1995 was highly conserved across different species, indicating possible impact on the protein function (Figure 2a). According to the PROSITE and SMART, p.C502 is located in the...