Predictions from the SNP interaction-based polygenic risk score based on 24 SNP pairs are promising. The prevalence of PCa aggressiveness was 49.8%, 21.9%, and 7.0% for the PCa cases from our cohort with the top 1%, middle 50%, and bottom 1% risk profiles. Potential biological functions of...
Interestingly, the SNP-SNP interaction of HOTAIR rs1899663 with HOTTIP rs1859168 strongly increased the risk of GC (rs1899663 GT-rs1859168 CC, OR = 4.3; rs1899663 TT-rs1859168 CC, OR = 9.37; rs1899663 TT-rs1859168 CA, OR = 6.59). We showed that the HOTAIR rs17720428, rs7958904,...
also at the level of 5%. forward stepwise selection procedure has proven to be efficient in assessing interaction effects as compared to backward elimination when testing multiple interactions. first, it is more time efficient and second, when using backward elimination, a relatively large number of...
Forward stepwise selection procedure has proven to be efficient in assessing interaction effects as compared to backward elimination when testing multiple interactions. First, it is more time efficient and second, when using backward elimination, a relatively large number of predictor variables may ...
Description : An R package to compute p-values for the interaction term in a very large number of linear regression models. PupaSNP Finder Description : A web-based tool for finding SNPs with putative effect. PupasView Description : A web-based SNP analysis tool for a selection of single ...
SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns. EGFR-MMP16 and EGFR-CSF1 were found to be associated with prostate cancer aggressiveness with the exact or similar pattern in the discovery and validation... HY Lin,DT Chen,PY Huang,... - 《Bioi...
Functional annotation results revealed that both SNPs might be involved in transcriptional regulation of gene expression. Our results suggest that a combined effect of SNPs via WNT4-WNT5A interaction may affect the variation of BMI in Han Chinese population. 展开 ...
The simulation results show that SIPI has higher power than MDR (Multifactor Dimensionality Reduction), AA_Full, Geno_Full (full interaction model with additive or genotypic mode) and SNPassoc in detecting interactions. Applying SIPI to the prostate cancer PRACTICAL consortium data with approximately ...
CHR1 Chromosome of first SNP SNP1 Identifier for first SNP CHR2 Chromosome of second SNP SNP2 Identifier for second SNP OR_INT Odds ratio for interaction STAT Chi-square statistic, 1df P Asymptotic p-value test.epi.cc.summary文件如下所示: 不同列所代表的意思: CHR Chromosome SNP SNP identif...
The extent of data in a typical genome-wide association study (GWAS) poses considerable computational challenges to software tools for gene-gene interaction discovery. Exhaustive evaluation of all interactions among hundreds of thousands to millions of s