with the sign of the effect on the outcome flipped). The slope of the line represents the causal association, and each method has a different line. The Egger estimate is the only line which doesn't automatically pass through
532413_a_g 0.0030 -0.133573470 0.10686249 0.2113 538622 OUTCOME MR_KEEP 1: outcome TRUE 2: outcome TRUE 3: outcome TRUE 4: outcome TRUE 5: outcome TRUE 6: outcome TRUE > head(formatted_AS) SNP chr.outcome pos.outcome effect_allele.outcome other_allele.outcome 1 1:61743_c_g 1 61743 C...
[13]Qu H, Du Y, Yu Y, et al. The effect of endometriosis on IVF/ICSI and perinatal outcome: a systematic review and meta-analysis[J]. J Gynecol Obstet Hum Reprod, 2022, 51(9): 102446. DOI: 10.1016/j.jog...
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma . J Invest Dermatol . 2012; 132 : 1471–1478. doi: 10.1038/jid.2012.15Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of ...
To identify the combined effect of several SNPs on each outcome separately, we exploited the methodology proposed in [10]. Thanks to that, we were able to summarize a patient’s genetic information into a risk (RS) and a protection (PS) score that respectively indicate an increase or decreas...
SMUT多SNP中介效应交叉联合检验包说明书 Package‘SMUT’October12,2022 Type Package Title Multi-SNP Mediation Intersection-Union Test Version1.1 Author Wujuan Zhong Maintainer Wujuan Zhong<***> Description Testing the mediation effect of multiple SNPs on an outcome through a mediator. LazyData true L...
However, polygenic models suggest that multiple commonly occurring low to modestly penetrant SNPs of cancer related genes might have a greater effect on a disease when considered in combination. Methods In an attempt to identify the breast cancer risk conferred by SNP interactions, we have studied ...
analysed using the same model, but without the probit link. Prior assumptions are weak with an uninformative prior followingσa2∼inv−gamma(0.01,0.01)andσhys2∼inv−gamma(0.01,0.01).yiis the vector of observations. Next to EKA also days in milk (DIM) was chosen as fixed effect. ...
However, polymorphisms located in the promoter region of the leptin gene (i.e. the region of the gene that regulates the level of leptin expression through its associated enhancer and silencer elements) may have a stronger effect on the regulation of these economically important traits, and ...
The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study. BMC Cancer 2013; 13:330; PMID:23829168; http://dx.doi.org/10.1186/1471-2407-13-330...