Parkinson’s disease (PD) is traditionally associated with motor symptoms. Non-motor deficits have received less attention but are also quite common and can even precede motor symptoms. PD patients can display a wide range of cognitive deficits of various intensity from Mild Cognitive Impairment (MC...
Introduction: It is well known that alpha-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to eva...
•This is the first genetic study demonstrating genes predicating the progression of Parkinson's disease in Chinese patients.•Motor performance was assessed using UPDRS and H&Y stages and cognitive performance using MMSE.•Genetic associations with the severity of Parkinson's disease and with dura...