Pihlstrom, L., and Toft, M. (2011). Genetic variability in SNCA and Parkinson's disease. Neurogenetics 12, 283-293. doi: 10.1007/s10048-011-0292-7Pihlstrom L, Toft M (2011) Genetic variability in SNCA and Parkinson’s disease. Neurogenetics 12:283–293...
Head injury and genetic variants of the α-synuclein-encoding SNCA might co-influence susceptibility to Parkinson disease (PD), a new study shows. Regression analysis of history of head injury and SNCA alleles in 561 individuals with idiopathic PD and 721 controls indicated that certain SNCA ...
Aims To investigate the association of several single nucleotide polymorphisms (SNPs) within alpha﹕ynuclein (SNCA) gene, and additional geneenvironment interaction with Parkinson's disease (PD) risk. Methods Hardy￤einberg equilibrium (HWE) is tested for controls using SNPstats (http://bioinfo.ic...
The "Iowa kindred," a large Iowan family with autosomal-dominant Parkinson's disease, has been followed clinically since the 1920s at the Mayo Clinic. In 2003, the genetic cause was determined to be a 1.7鈥塎b triplication of the alpha-synuclein genomic locus. Affected individuals present ...
Hu Y, Tang B, Guo J, Wu X, Sun Q, Shi C, Hu L, Wang C, Wang L, Tan L, Shen L, Yan X, Zhang H (2012) Variant in the 3′ region of SNCA associated with Parkinson’s disease and serum alpha-synuclein levels. J Neurol 259(3):497–504. : 10.1007/s00415-011-...
It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the associ...
inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. ...
Genome-wide association studies have demonstrated association between SNCA variability and susceptibility to Parkinson's disease, but causal mechanisms are unclear. We hypothesized that risk variants affect methylation of a putative promoter in SNCA intron 1, previously highlighted in epigenetic studies of ...
the snca gene encodes α-synuclein, a small (140 amino acid) protein localized, in part, to presynaptic terminals that modulates vesicle trafficking and neurotransmitter release. a link between α-synuclein and parkinson disease (pd) was first demonstrated in 1997 when a missense mutation (a53t)...
Cognitive impairments are prevalent in Parkinson’s disease (PD), but the underlying mechanisms of their development are unknown. In this study, we aimed to predict global cognition (GC) in PD with machine learning (ML) using structural neuroimaging, gen