Polymorphisms in the SNCA gene: association with the risk of development of the sporadic form of Parkinson's disease and the level of SNCA gene expression in peripheral blood of patients from Russia. Neurosci. Med. 4, 208-214.Alieva AK, Shadrina MI, Filatova EV, Ustinova VV, Fedotova EY...
The G51D mutation in the SNCA gene encoding α-synuclein causes an aggressive, early-onset form of PD that exhibits clinical and neuropathological traits reminiscent of both PD and MSA. To assess the strain characteristics of G51D PD α-synuclein aggregates, we performed propagation studies in...
The Thy1SNCA/15 mice overexpress 1–2 copies of the gene encoding human wild-type αSyn that is driven by the mouse thymus cell antigen 1 (Thy1) promoter leading to neuronal expression of αSyn in the brain and gut [7, 8, 60]. Thy1SNCA/15 mice were first described by Choi et al...
The effects of the tau gene (MAPT) H1 haplotype, the H1 specific SNP rs242557, APOE and the α-synuclein gene (SNCA) 3′UTR SNP rs356165 on the burden of AD and LB pathology were assessed. Neurofibrillary tangles (NFTs) were counted in four brain regions, senile plaques in five and ...
Full size table In comparison with other reported mutations in theSNCAgene, the age of onset in this family, clinical features and progression are most similar to theSNCAtriplication [16] and A53T mutations, which are typically associated with young-onset PD frequently associated with cognitive imp...
Polymorphisms in the SNCA gene: association with the risk of development of the sporadic form of Parkinson's disease and the level of SNCA gene expression in peripheral blood of patients from Russia. Neurosci. Med. 4, 208-214.Alieva AK, Shadrina MI, Filatova EV, Ustinova VV, Fedotova EY...