Introduction: This study aimed to investigate the effect of smoking cessation on plasma clozapine (CLO) concentrations in long-term hospitalized Chinese male patients with schizophrenia treated with CLO during the COVID-19 pandemic. Methods: Therapeutic drug monitoring (TDM) data for CLO...
Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia: effect of smoking. Concentrations in plasma of clozapine and norclozapine, the major metabolite of clozapine, were measured in 59 treatment-resistant schizophrenic patients a... M Hasegawa,R Gutierrez-Esteinou...
[Effect of smoking and storing ear corn on stacked racks on its keeping quality] Aims: Cytochrome P4501A2 (CYP1A2) is involved in the metabolism of severaldrugs (clozapine, olanzapine, theopylline, caffeine, etc) and is induced by smoking.This can result in decreased plasma levels of drugs...
CYP2A1/2A2 and CYP2B1/2B2, in the brain, but whether this effect is clinically significant is unknown. Similarly, although inhibitory effects of the smoke constituents carbon monoxide and cadmium on CYP enzymes have been observedin vitroand in animal studies, the relevance of this inhibition to...
(CYP) 1A2 through activation of the aromatic hydrocarbon receptor, and the induction effect between the two products is additive. Smoking cessation is associated with rapid downregulation of CYP1A enzymes. On the basis of the estimated half-life of CYP1A2, dose reduction of CYP1A drugs may be...
Switching From Tobacco Smoking to Electronic Cigarettes and the Impact on Clozapine Levels FIGURE 1. Clozapine dosage (inmg/d) and blood serum levels (in ng/mL) over the course of inpatient treatment, before and after switching from smoking combustible (CC) to e-cigarettes (EC). The gray ba...
Studies suggest that the beneficial effect of fluvoxamine augmentation in raising serum clozapine concentrations also occurs when serum concentrations are low due to smoking. Yet, little is known about the influence of fluvoxamine augmentation on clozapine serum concentrations in smoking versus non-smoking...
smokingObjective The efficacy of clozapine clearance has been shown to be associated with smoking and genetic polymorphism of CYP1A2. This study aims to investigate the effect of smoking on the plasma level of clozapine in Taiwanese schizophrenic patients and its relevance to the CYP1A2 gene - ...
When comparing their clozapine dose and body weight-related serum drug levels, we found that clozapine and demethylclozapine concentrations were about 40% lower in the smoking than in the non-smoking group, probably due to an inducing effect of smoking on the cytochrome P450 (CYP) 1A2, which...
( 1994 ) Seizure following smoking cessation in a clozapine responder . Pharmacopsychiatry 27 : 210 – 211 .McCarthy, R. H. : Seizures following smoking cessation in a clozapine responder . Pharmacopsychiatry 1994 , 27 , 210 – 211 .