Yet, little is known about the influence of fluvoxamine augmentation on clozapine serum concentrations in smoking versus non-smoking patients. A TDM database was analyzed. Serum concentrations of CLZ, NCLZ, dose-adjusted serum concentrations (C/D) and metabolite-to-parent ratios (MPR) were ...
(Ps0.05),while the social function,social interest,total positive factor scores of NOSIE in smokers were significantly higher(Ps0.05).However,the cigarette smoking dose was not correlated with the scores of PANSS and NOSIE(P0.05).Conclusions Smoking may be a self-treatment behavior for patients ...
Increased cortical inhibition in persons with schizophrenia treated with clozapine. J Psychopharmacol 22: 203–209. Article CAS PubMed Google Scholar Dani JA (2001). Overview of nicotinic receptors and their roles in the central nervous system. Biol Psychiatry 49: 166–174. Article CAS PubMed ...
Introduction: No study has investigated the impact of smoking habits and concomitant valproic acid (VPA) use on clinical outcomes in maintenance treatment with clozapine. Thus, we aimed to examine the effect of smoking habits and concomitant VPA use on relapse during the first year after discharge...
psychoactive drugs that are likely to have their plasma levels increased after smoking cessation include: clomipramine, clozapine, desipramine, desmethyldiazepam, doxepin, fluphenazine, haloperidol, imipramine, oxazepam, nortrip- tyline, and propranolol (Table).20 The plasma level of caffeine is also ...
Aims: Cytochrome P4501A2 (CYP1A2) is involved in the metabolism of severaldrugs (clozapine, olanzapine, theopylline, caffeine, etc) and is induced by smoking.This can result in decreased plasma levels of drugs metabolized by thisisoenzyme, causing a decrease ...
Thus smoking cessation in patients while they are undergoing therapy with a CYP1A2 substrate such as theophylline or clozapine increases its concentrations and may cause adverse effects. Our objective was to determine the time course of CYP1A2 activity changes after smoking cessation in heavy smokers...
Thus smoking cessation in patients while they are undergoing therapy with a CYP1A2 substrate such as theophylline or clozapine increases its concentrations and may cause adverse effects. Our objective was to determine the time course of CYP1A2 activity changes after smoking cessation in heavy smokers...
Wagner, E.; McMahon, L.; Falkai, P.; Hasan, A.; Siskind, D. Impact of Smoking Behavior on Clozapine Blood Levels-A Systematic Review and Meta-Analysis.Acta Psychiatr. Scand.2020,142, 456–466. [Google Scholar] [CrossRef] [PubMed] ...