Clozapine-resistant psychosis, smoking, and caffeine: managing the neglected effects of substances that our patients consume every day. Am J Ther 2007;14(3):314-8.Dratcu L, Grandison A, McKay G, Bamidele A, Vas
While only one participant raised this issue, it is important as it highlights the added complexity involved in stopping smoking when a person has a mental health problem and has been prescribed medications such as clozapine, which is an anti-psychotic. Smoking induces an enzyme which is involve...
Smoking is associated with increased clearance of tiotixene, fluphenazine, haloperidol and olanzapine. Plasma concentrations of chlorpromazine and clozapine are reduced by cigarette smoking. Clinically, reduced drowsiness in smokers receiving chlorpromazine, and benzodiazepines, compared with non-smokers has bee...
Empty Cell Clozapine(Clozaril) + (D) + : efficacious and clinically useful; -: not useful; + /-: likely efficacious and possibly useful; I: insufficient evidence and investigational. The most recent Evidence-Based Medicine (EBM) review by Fox et al. (2018) and another review by ...
SUGGESTED for you The researchers conducted a population-based, nested, case-control study of all live births in Finland from 1983 through 1998. Maternal serum cotinine levels were prospectively measured from early to mid gestation using serum samples archived in a national biobank. ...
Hinterhuber, Dose-related plasma levels of clozapine: Influence of smoking behaviour, sex and age, Psychopharmacology 99 (1989) S38.Haring C, Meise U, Humpel C, Saria A, Fleischhacker WW, Hinterhuber H. Dose-related plasma levels of clozapine: Influence of smoking, behaviour, sex and age....
Behavioural and psychosocial interventions also demonstrate promise, particularly when combined with pharmacotherapy. Careful monitoring of antipsychotic levels (in particular clozapine) is essential, and the promotion of physical activity may be useful to negate potential weight gain and diabetes ...
Conclusion: The findings suggest that the combination of smoking habits and concomitant VPA use may increase the risk of relapse after discharge. Future studies are required to elucidate the mechanisms underlying these findings, such as a decrease in clozapine blood levels....
The antipsychotic agent clozapine is frequently used in patients with treatment-resistant psychotic illnesses such as schizophrenia and schizoaffective disorder. It is well established that cigarette smoking reduces circulating levels of clozapine, thereby limiting its efficacy. Here, Dr Cooney et al. ...
psychoactive drugs that are likely to have their plasma levels increased after smoking cessation include: clomipramine, clozapine, desipramine, desmethyldiazepam, doxepin, fluphenazine, haloperidol, imipramine, oxazepam, nortrip- tyline, and propranolol (Table).20 The plasma level of caffeine is also ...