Two cases of patients who smoked tobacco and cannabis are reported. The first patient, who was receiving clozapine treatment, developed confusion after tobacco and cannabis smoking cessation, which was related to increased clozapine plasma levels. The second patient, who...
Smoking is associated with increased clearance of tiotixene, fluphenazine, haloperidol and olanzapine. Plasma concentrations of chlorpromazine and clozapine are reduced by cigarette smoking. Clinically, reduced drowsiness in smokers receiving chlorpromazine, and benzodiazepines, compared with non-smokers has bee...
Yet, smoking can have effects on the metabolism of antipsychotic medications, especially clozapine and olanzapine, such as decreasing their blood levels and increasing the clinically effective dose [43]. Therefore, it has been suggested that doses of clozapine and olanzapine be increased by 50 and ...
Estimating the incidence and the prevalence of psychotic disorders in the province of Quebec has been the object of some interest in recent years as a cont... J Dirk - 《Bmj》 被引量: 0发表: 2019年 Switching From Tobacco Smoking to Electronic Cigarettes and the Impact on Clozapine Levels ...
Empty Cell Clozapine(Clozaril) + (D) + : efficacious and clinically useful; -: not useful; + /-: likely efficacious and possibly useful; I: insufficient evidence and investigational. The most recent Evidence-Based Medicine (EBM) review by Fox et al. (2018) and another review by ...
Both patients experienced a major, sustained amelioration of their psychotic symptoms when clozapine treatment was recommenced under supervision in the inpatient setting and the pharmacological interactions between clozapine, smoking, and caffeine were considered. Therapeutic strategies included gradual increases...
psychoactive drugs that are likely to have their plasma levels increased after smoking cessation include: clomipramine, clozapine, desipramine, desmethyldiazepam, doxepin, fluphenazine, haloperidol, imipramine, oxazepam, nortrip- tyline, and propranolol (Table).20 The plasma level of caffeine is also ...
The antipsychotic agent clozapine is frequently used in patients with treatment-resistant psychotic illnesses such as schizophrenia and schizoaffective disorder. It is well established that cigarette smoking reduces circulating levels of clozapine, thereby limiting its efficacy. Here, Dr Cooney et al. ...
ClozapineSchizophreniaSmoking抗精神病剂氯氮平精神分裂症吸烟Serum concentrations of clozapine and its main metabolite demethylclozapine were measured in 44 schizophrenic inpatients, of whom ten were non-smokers and 34 smokers. When comparing their clozapine dose and body weight-related serum drug levels, ...
clozapinepaliperidonereadmissionsmokingBackground: Clozapine levels are severely decreased by cigarette smoke hydrocarbons. A new agent that is unaffected by smoking is paliperidone palmitate. Objective: The purpose of this study is to retrospectively evaluate hospital readmission and time until ...