ClozapineSchizophreniaSmoking抗精神病剂氯氮平精神分裂症吸烟Serum concentrations of clozapine and its main metabolite demethylclozapine were measured in 44 schizophrenic inpatients, of whom ten were non-smokers and 34 smokers. When comparing their clozapine dose and body weight-related serum drug levels, ...
Repeat plasma level a week after cessation and consider further dose reduction Risperidone Monitor Haloperidol Reduce dose by 25%, monitor carefully, and consider further dose reductions Clozapine Take plasma level before stopping. On stopping, gradual 25% dose reduction over a week. Repeat plasma ...
Pharmacodynamic interactions have also been described. Cigarette smoking is associated with a lesser magnitude of blood pressure and heart rate lowering during treatment with β-blockers, less sedation from benzodiazepines and less analgesia from some opioids, most likely reflecting the effects of the st...
Switching From Tobacco Smoking to Electronic Cigarettes and the Impact on Clozapine Levels FIGURE 1. Clozapine dosage (inmg/d) and blood serum levels (in ng/mL) over the course of inpatient treatment, before and after switching from smoking combustible (CC) to e-cigarettes (EC). The gray ba...
Smoking and other factors of cornary heart disease risk (author's transl) Aims: Cytochrome P4501A2 (CYP1A2) is involved in the metabolism of severaldrugs (clozapine, olanzapine, theopylline, caffeine, etc) and is induced by smoking.This can result in decreased plasma levels of drugs metaboli...
Switching From Tobacco Smoking to Electronic Cigarettes and the Impact on Clozapine Levels The liquid evaporates at the heating device and is then rapidly cooled. This leads to the formation of an aerosol that can be inhaled. Consumers consider e-cigarettes as less harmful than combustible cigarettes...
Serum TNF-α, IL-10 and IL-2 in schizophrenic patients before and after treatment with risperidone and clozapine. Serum concentrations of were lower than the detection limit of assay and were not detectable. In comparison with healthy controls, serum concentrations of -α in schizophrenic patients...
Tobacco smoke contains a large number of compounds in the form of metals, volatile gases and insoluble particles, as well as nicotine, a highly addictive alkaloid. Marijuana is the most widely used illicit drug of abuse in the world, with a significant increase in the USA due to the increasi...
Behavioural and psychosocial interventions also demonstrate promise, particularly when combined with pharmacotherapy. Careful monitoring of antipsychotic levels (in particular clozapine) is essential, and the promotion of physical activity may be useful to negate potential weight gain and diabetes r...
This study aimed to evaluate the influence of cigarette smoking habit on the clozapine (CLZ)-to-norclozapine (norCLZ) ratio in male patients.#The sample consisted of plasma concentration of CLZ and norCLZ data set. The mean values of CLZ, norCLZ, and CLZ-to-norCLZ, between male patients...