Cerebral small vessel disease (cSVD) is a collective term for different pathological processes that affect the small vessels of the brain, i.e. the small arteries and veins and the capillary beds. cSVD accounts for a quarter of ischemic strokes and is a main cause of vascular dementia (Debet...
The blood vessel growth inhibitor bevacizumab targets vascular endothelial growth factor (VEGF), a crucial regulator of angiogenesis. Recently, small extracellular vesicles (sEVs) have been demonstrated to be important vehicles in the transport of growth factors to target cells. In this study, we iso...
This can partly be explained by a lack of or a faint effect of antihypertensive therapy on the increased blood–brain barrier (BBB) permeability14, which, along with ischemia, is another significant mechanism of brain damage in hypertension15,16,17. BBB damage in patients with hypertension is ...
brain ischemiablood brain barrierSmall vessel disease (SVD) is responsible for brain chronic circular disorder, and accounts for 20%-30% cases of ischemic stroke as well as cerebral hemorrhage, and to a great extent, encephalopathy. Binswanger's disease and multiple small strokes, which are ...
(total and periventricular) are focal and multifocal confluent lesions of white matter injury that reflect axonal loss due to chronic ischemia caused by cSVD5,11,12. Studies have shown that extensive WMH burden is associated with an increased risk of incident stroke and dementia. The initial ...
White matter lesion progression: A surrogate endpoint for trials in cerebral small-vessel disease White matter lesion progression: A surrogate endpoint for trials in cerebral small-vessel disease. Neurology. 2004;63:139 -144.Schmidt R, Scheltens P, Erkinjuntti T, Pantoni L, Markus HS, Wallin A...
Acute and chronic upper extremity ischemia: I. large vessel arterial occlusive disease. Ann Vasc Surg 7:106-112, 1993Fujitani RM, Mills JL. Acute and chronic upper extremity ischemia. I. Large vessel arterial occlusive disease. Ann Vasc Surg, 1993, 7:106-112. (收稿日期:2013-07-01) (助理...
and ischemia in this area64. The increased expression of adhesion molecules might lead to an increased number of T cells in SHR brains. On one hand, T cells adhering to the lumen side of brain microvessels might be part of the systemic adaptive immune response to angiogenesis antigens during...
86What is the difference between occlusive and nonocclusive small intestinal ischemia? Occlusive ischemia results from thrombi or emboli occluding the main trunk or several branches of the superior mesenteric artery. Thrombi account for most of such occlusions. These thrombi usu...
treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The ...