The sequelae of cerebral ischemia-reperfusion injury are reduced by administering to the subject a pharmaceutical composition that includes a pharmaceutically acceptable carrier and a therapeutically effective amount of an agent that selectively binds IL-lα.CAMICI, GIOVANNI, GUIDO...
Brain is very vulnerable to ischemia, and exhibits various functional impairments in a flow-dependent manner. After onset of ischemia, the following cascade ensues propagating from the ischemic core to the surrounding area; ischemic depolarization, excitatory cellular injury induced by Ca(2+) and glut...
Brain injury after stroke requires glutamate receptor activation of neuronal nitric oxide synthase (nNOS), but inhibiting either of these proteins can cause side effects. Now, Dong-Ya Zhu and colleagues show that a drug that blocks the interaction betwee
The recovery of blood circulation following cerebral infarction-associated thrombolysis brings new damage to the brain, which is cerebral ischemia-reperfusion injury (CIRI). Inflammation is the main pathological mechanism of CIRI. The inflammatory response triggered by cerebral ischemia-reperfusion provides ...
Our study realized an improved neuroprotective efficiency of citicoline by stereotactic delivery, and an optimal therapeutic effect of this administration pathway can be achieved under MRI guidance. 展开 关键词: Blood brain barrier stereotactic delivery magnetic resonance imaging neuroprotection brain ischemia...
Multiple mechanisms by which hyperglycemia may augment acute ischemic brain injury have been suggested, including increased inflammatory response and oxidative stress.27 The intention of the 12-hour eligibility window for this trial was to start treatment prior to the occurrence of substantial injury, wh...
concept, ischemic stroke has been recognized as a dynamic process and two main therapeutic strategies have been designed: one that tries to reopen the occluded artery and the second aims to protect the penumbra brain tissue until the physiologic mechanisms-or the treatment-stop the ischemia. OBJECTI...
(2)emergent-出现的(treatment-emergent 治疗后出现的)举个例子,接受抗菌药物后,出现了帕金森,虽然与研究药物无关,但是是在接受药物后出现的,可确定为“治疗后出现的不良事件(TEAE)” (3)related-相关的(treatment-related治疗相关的)举个例子,接受抗高血压药物后,出现了低血压。这个可能是治疗相关的不良事件(TRAE...
of Willis, as seen in this patient from the vignette. Subarachnoid hemorrhage can extend beyond the basal cisterns into the sylvian fissures or into the ventricles or brain parenchyma. The distribution of blood offers clues to...
24 August 2016 Treatment of surgical brain injury by immune tolerance induced by intrathymic and hepatic portal vein injection of brain antigens Weijian Yang1,2,Yong Liu1, Baolong Liu3, Huajun Tan1, Hao Lu1, Hong Wang2 & Hua Yan2,4 Surgical brain injury (SBI) defines co...