Despite significant progress in understanding of the potential of adenosine A1 receptor-based therapies in treatment of cerebral ischemia and stroke, very little is known about the effect of selective stimulation of adenosine A2A receptors on the outcome of a cerebrovascular arrest. In view of a ...
Chronic cerebral ischemia (CCI) is a significant health issue characterized by hypoperfusion due to damage or occlusion of the cerebral or carotid arteries. CCI may lead to progressive cognitive impairment that is considered as a prelude to neurodegenera
Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
aThe results illustrate that chronic cerebral ischemia can down-regulate the expresstion of PSD95 significantly that affects synaptic plasticity and integrity. 结果说明慢性大脑局部缺血可能下来极大调控影响突触神经的可塑性和正直PSD95的expresstion。 [translate] ...
5) cerebral ischemia 脑供血不足 1. Methods The right cerebral ischemia in rats were formed by ligating their right cervical artery; and on 3d and 7~(th) day after ligat-ing, the peripheral RBC and their mobility were analyzed with instruments. 目的 研究羌菖合剂对脑供血不足大鼠外周红...
1) Chronic cerebral ischemia 慢性脑缺血 1. Effect of Heme Oxygenase-1 Gene on Cognitive Function and Oxidative Stress During Chronic Cerebral Ischemia in Rats; rAAV+HO-1基因对慢性脑缺血大鼠认知能力和氧化应激的影响 2. Advance in search for pathological mechanism and experimental study of chronic ...
Oxidative stress developing in these conditions promotes progression of cerebral ischemia, generating the need to correct any biochemical abnormalities which may be detected. Use of antioxidants in patients with cerebrovascular diseases and metabolic syndrome aids reductions in these main signs of metabolic ...
Immunologic tolerance to myelin basic protein decreases stroke size after transient focalcerebralischemia Immune mechanisms contribute to cerebral ischemic injury. Therapeutic immunosuppressive options are limited due to systemic side effects. We attempted to a... KJ Becker,RM Mccarron,C Ruetzler,... -...
Here we report that fluoxetine treatment (10 mg kg−1, i.p.) for 4 weeks promoted the survival of newborn cells in the ischemic hippocampus and, consequently, attenuated spatial memory impairment of mice after focal cerebral ischemia. Disrupting hippocampal neurogenesis blocked the beneficial ...
Chronic cerebral hypoperfusion leads to white matter injury (WMI), which subsequently causes neurodegeneration and even cognitive impairment. However, due