Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
This can partly be explained by a lack of or a faint effect of antihypertensive therapy on the increased blood–brain barrier (BBB) permeability14, which, along with ischemia, is another significant mechanism of brain damage in hypertension15,16,17. BBB damage in patients with hypertension is ...
During the first 6 months, patients are systematically reassessed clinically and by brain MRI: (1) at any time if stroke symptoms occur and (2) at the end of the period. We defined MRI-proven incident ischemia as either recurrent ischemic stroke or at least 1 incident lacune or incidental...
Although gastrointestinal complications are less common than cardiac damage, cocaine abuse may induce mesenteric ischemia as a result of vasoconstriction leading to gastric or intestinal ulceration and perforation of the entire wall.501,502 It appears that the abuse of the free base form of cocaine ...
(Fig.1). Post-stroke dementia is a major consequence after large vessel strokes. Approximately 10% of patients develop dementia after their first stroke [5]. Atherothrombotic brain infarcts [6] and hemorrhagic stroke [5,7] are associated with the higher dementia risk. Subcortical ischemic ...
The continued increase in global life expectancy predicts a rising prevalence of age-related cerebral small vessel diseases (CSVD), which requires a better understanding of the underlying molecular mechanisms. In recent years, the concept of “inflammagi
Change in whole-brain cerebral blood flow did not significantly differ between standard vs intensive groups. Meaning Intensive blood pressure lowering did not cause hypoperfusion in severe cerebral small vessel disease. Abstract Importance Blood pressure (BP) lowering is considered neuroprotective in ...
Ischemia causes pathologic changes when the perfusion of the intestines declines below 50% of normal. ▪ The small intestinal blood is supplied by the superior mesenteric artery, the branches of which form anastomosing arcades. Ischemia develops only if more than one of the...
to vascular dementia mouse models has been shown to attenuate cognitive dysfunction and protect against cerebral ischemia/reperfusion injury41. Gut dysbiosis has also been associated with cSVD, where patients with Enterotype I were more likely to have cognitive decline and high total cSVD scores42. ...
. Similarly, among the loci which were not reported in previous publications, our analyses point to an association ofCD82(Cluster of Differentiation 82) with FA and MD in the brain. One might expect these genes to be involved predominantly in the response of the brain parenchyma to ischemia....