Background Neuropsychiatric symptoms (NPS) are important as they impact the quality of life of patients with dementia and increase burden to care givers. About 90% of patients with Alzheimer's disease (AD) and about 92% of patients with vascular dementia (VaD) experience NPS. When comparing ...
Intramural ("small vessel") coronary artery disease in hypertrophic cardiomyopathy Many patients with hypertrophic cardiomyopathy have signs and symptoms of myocardial ischemia and dysfunction. Although hypertrophy and increased left vent... BJ Maron,JK Wolfson,SE Epstein,... - 《Journal of the ...
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
The Role of Small Vessel Disease in Myocardial Infarction T HE clinical characteristics of myocardial infarction depend not only on the amount of damage but in great measure on where it occurs in the heart. Clear examples of this are provided when the sinus node, the His bundle, or the papi...
White matter microstructural damage and depressive symptoms in patients with mild cognitive impairment and cerebral small vessel disease: the VMCI-Tuscany ... Disruption of cortical-subcortical circuits related to small vessel disease (SVD) may predispose to depression in the elderly. We aimed to deter...
Both ISMN and cilostazol have been widely used for ischemic heart disease, peripheral vascular disease, or secondary prevention of atherothromboembolic stroke for years, with known, acceptable safety profiles. Despite concerns that adverse symptoms attributable to these drugs would discourage compliance, ...
Cerebral small vessel disease (CSVD) plays an important role in cognitive impairment, stroke, disability, and death. Hypertension is the main risk factor for CSVD. The use of antihypertensive therapy has not resulted in the expected decrease in CSVD complications, which may be related to the unde...
Depression and brain aging may occur simultaneously, and elevated symptoms of depression may affect the brain through small vessel disease, a longitudinal study of older adults suggested. Greater depressive symptoms -- defined as a Center of Epidemiological Studies Depression Scale score of ≥16 -- ...
the relationship between gut dysbiosis and markers of cerebral small vessel disease (cSVD), a major contributor to ADRD, is unknown. In this cross-sectional study, we examined the connection between the gut microbiome, cognitive, and neuroimaging markers of cSVD in the Framingham Heart Study (FHS...
The continued increase in global life expectancy predicts a rising prevalence of age-related cerebral small vessel diseases (CSVD), which requires a better understanding of the underlying molecular mechanisms. In recent years, the concept of “inflammagi