ObjectiveTo investigate the clinical effect of a heterozygous missense variant of HTRA1 on cerebral small vessel disease (CSVD) in a large Japanese family with a p.A252T variant.MethodsWe performed clinical, laboratory, radiologic, and genetic evaluations of members of a previously reported family ...
Whether white matter lesion (WML) is associated with vascular cognitive impairment in cerebral small vessel disease (CSVD) remains controversial; some severe CSVD patients retain normal cognitive function, and cortical thinning associated with WMLs has also been recently reported. The contribution of cort...
Acute kidney injury (AKI) is common in critical cases of coronavirus disease 2019 (COVID-19) and associated with worse outcome. Dysregulated neutrophil extracellular trap (NET) formation is one of several suggested pathophysiological mechanisms involved in the development of COVID-19 associated AKI. ...
knowlesi malaria (absence of retinopathy) but signs and symptoms associating respiratory distress syndrome, circulatory shock, and hepatic and renal impairment are common. As the parasitic life cycle is 24 hours, parasitemia may increase more rapidly than with P. falciparum. This explains why the ...
Common (1% to 10%): Dystonia, extrapyramidal symptoms (EPS), headache, other EPS-related events, parkinsonism Frequency not reported: Abnormal coordination, akinesia, bradykinesia, cerebrovascular adverse reactions, choreoathetosis, cognitive/motor impairment, dizziness, hypokinesia, increased mortality in ...
Frequency not reported: Drug rash with eosinophilia and systemic symptoms (DRESS)Rash included rash, erythematous rash, follicular rash, generalized rash, macular rash, maculopapular rash, papular rash, pruritic rash, exfoliative rash, genital rash, pustular rash, dermatitis, acneiform dermatitis, aller...
HCV RNA viral load was posi- tive on the first blood test and persistent more than 6 months before the onset of neurological symptoms. Meanwhile, liver enzymes were initially positive on the first blood test then negative on the liver function test withdrawn at emergency admission with a new ...
IPSS-QoL assesses the quality of life associated with symptoms from urinary problems. The BII is a self-reported, validated, disease-specific instrument for quantifying the interference of LUTS on the patient’s mental health and activity. As a measure of QoL, it is used to determine treatment...
Currently, the diagnosis of GPA depends solely on clinical symptoms. While pathological biopsy is the gold standard for diagnosing GPA, atypical cases are diagnosed with the assistance of serological examinations. The early diagnosis of GPA is important for the treatment and prognosis of this disease...
To this end the kinetics of the serological responses along with the correlation between the antibody titers and disease outcome have been assessed. It has been found that antibody titers gradually increased for up to 3 weeks since the onset of symptoms for patients requiring oxygen supplementation ...