Small vessel disease (SVD) is a pathology that affects microcirculation in the brain and can be detected by imaging techniques such as magnetic resonance and computed tomography. SVD leaves a heterogeneous phenotype of imaging markers, ranging from white matter changes to microbleeds. The pathogenesis...
dyspnea symptoms and exacerbations[17]. The chronic bronchitis phenotype seemed to have less influence although numbers of COPD subjects conferring this phenotype were low[17]. Because small vessel disease can lead to thrombosis and subsequent stroke due to lipohyalinosis, fibrinoid degeneration or athe...
Small vessel ischemic disease can present itself in mild, moderate, or severe forms. Most older adults, particularly those with a mild form of the disease, are asymptomatic; that is, they show no symptoms of the disease even when there are visible damage areas (through MRI scan) in the bra...
The main disease symptoms were cognitive impairment, gait disturbances unrelated to post-stroke hemiparesis, and MRI changes including WMH, lacunae, microbleeds and dilated perivascular spaces (Table 2). Table 2 Clinical symptoms and MRI signs in patients with CSVD. Full size table Differences in mea...
Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 indepe...
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
Chronic cerebral hypoperfusion (CCH) is a critical pathophysiological mechanism underlying cerebral small vessel disease (CSVD). Accumulating evidence have demonstrated that resident pericytes and deposit extracellular matrix (ECM) and play a key role in mediating fibrosis in hypoxic changes. Edaravone dex...
Health-care providers are often confronted with patients that present with anginal symptoms, but on coronary angiography are found to have nonobstructive coronary artery disease (CAD) (Patel et al., N Engl J Med 362:886–895, 2010). Many times, chest pai
blood pressure [189]. Hypertension is also the most consistent predictor of cerebral microhemorrhage in healthy adult individuals and stroke patients [165]. While blood pressure variability has been shown to correlate with cardiovascular disease risk [190], it is also involved in cSVD development. ...
In addition to intraparenchymal hemorrhage, the development of nontraumatic, convexity subarachnoid hemorrhage (SAH) due to cerebral small vessel disease can also be seen when accounting for the manifestations of CAA [33]. Symptoms are usually focal neurological deficits that can wax and wane recurrent...