Small vessel disease of the brain could be clinically silent, or manifested through a heterogeneous spectrum of diseases, where cognitive decline and stroke-related symptoms are the most common ones. Prevention and therapy are centered around vascular risk factor control, physically and cognitively ...
small vessel disease Acronyms Any of multiple small cerebral infarcts in the corona radiata, internal capsule, striatum, thalamus, basis pontis, and/or cerebellum, occasionally preceded by transient symptoms, due to occlusion or stenosis of small penetrating branches of the middle and posterior cerebral...
doi:10.1001/jamanetworkopen.2024.7034 Key Points Question What are the missing gene variants in cerebral small vessel disease (CSVD)? Findings This 2-stage study involved linkage analysis among 2 large families, including 9 patients with CSVD, and a case-control study of 2 probands from these ...
Introduction: Not only is small vessel disease (SVD) common, especially in older individuals, it often occurs silently and manifests insidiously, with the result that the scope of the problem is under-recognized. The manifestations of SVD are widespread, with an impact on psychiatric status, qual...
Increasing small vessel disease burden is associated with risk of incident stroke and dementia, as well as other neuropsychiatric symptoms. Current research strategies are targeting elucidation of the mechanisms of small vessel disease pathogenesis and pursuing clinical trials of therapeutic agents to ...
Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease. AIM: The authors investigated the prevalence of behavioural and psychological symptoms in (VaD) from baseline data of the VantagE study and compared the se... SS Staekenborg,T Su,ECW ...
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment. Objective To test the feasibility, drug tolerability, safety, and effects of 1-...
Cerebral small vessel disease (CSVD) plays an important role in cognitive impairment, stroke, disability, and death. Hypertension is the main risk factor for CSVD. The use of antihypertensive therapy has not resulted in the expected decrease in CSVD complications, which may be related to the unde...
A bidirectional communication exists between the brain and the gut, in which the gut microbiota influences cognitive function and vice-versa. Gut dysbiosis has been linked to several diseases, including Alzheimer's disease and related dementias (ADRD). H