Small Blood Vessel Disease in the Brain Theme Issue Overlapping protein accumulation profiles of CADASIL and CAA: Is there a common mechanism driving cerebral small vessel disease?CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and CAA (cerebral amyloid ...
关键词 blood-brain barrier dysfunction cerebral blood flow cerebral hypoperfusion endothelial dysfunction HYPERTENSION inflammation magnetic resonance imaging neurovascular unit oxidative stress small vessel disease tight junctions TRANSCYTOSIS 分类号 R743 [医药卫生—神经病学与精神病学] 相关...
small vessel disease Acronyms Any of multiple small cerebral infarcts in the corona radiata, internal capsule, striatum, thalamus, basis pontis, and/or cerebellum, occasionally preceded by transient symptoms, due to occlusion or stenosis of small penetrating branches of the middle and posterior cerebral...
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
The study included patients aged 46–70 years with cognitive and other neurological complaints, such as gait and balance problems, mood disorders or residual symptoms after stroke, brain changes on MRI corresponded to CSVD (WMH, lacunae, enlarged perivascular spaces, microbleeds and cerebral atrophy)...
Introduction: Not only is small vessel disease (SVD) common, especially in older individuals, it often occurs silently and manifests insidiously, with the result that the scope of the problem is under-recognized. The manifestations of SVD are widespread, with an impact on psychiatric status, qual...
Here, we show that bi-allelic NIT1 loss-of-function variants cause a genetic cerebral small vessel disease, resulting in a triad of movement disorders, massively dilated perivascular spaces on brain MRI, and fatal deep ICH. We describe the clinical phenotype, neuroimaging features, and brain vess...
Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Lancet Psychiatry. 2021;8(3):225-236. doi:10.1016/S2215-0366(20)30431-4 PubMedGoogle ScholarCrossref 2. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: ...
A bidirectional communication exists between the brain and the gut, in which the gut microbiota influences cognitive function and vice-versa. Gut dysbiosis has been linked to several diseases, including Alzheimer's disease and related dementias (ADRD). H
Youssef Z. Wadghiri2,3 & Balaji Sitharaman1 Current clinical Gd3+-based T1 magnetic resonance imaging (MRI) contrast agents (CAs) are suboptimal or unsuitable, especially at higher magnetic fields (>1.5 Tesla) for advanced MRI applications such as blood pool, cellular and molecular imaging...