as an inhibitor of ‘stemness’ of mammary stem cells and pluripotent stem cells and it may also have anti-tumorigenic activity in cancer stem cell populations21,22,23,24. One striking observation in our study is that other small ncRNA (snRNA, Y RNA, snoRNA, and piRNA) contaminants are ...
Abnormal plasma cell morphology by aspirate microscopy and clonality by FC correlated in 229 of 294 cases (78%). However, in 50 cases, FC demonstrated a monoclonal population but microscopy reported no abnormality. In 15 cases, abnormalities were reported by microscopy but not by FC. Clonality ...
371,372-374 Such transcripts have not been detected in other small cell tumors. The Ewing’s family of tumors is characterized by high MIC2/CD99 expression; that glycoprotein can be detected by various monoclonal antibodies, including HBA71, 12E7, RFB-1329, and 013 (see Table 4.3). It ...
the T-cell receptor signaling complex such as CD3 and T-cell receptors (eg, antibody βF-1). A subset of tumors lacks all T-cell antigens and has a null cell immunophenotype. However, both T- and null-cell ALK+ ALCL usually carry monoclonal rearrangements of the T-cell receptor genes....
Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need...
Daiichi Sankyo and AstraZeneca’s Biologics License Application for datopotamab deruxtecan has been accepted in the U.S. for the treatment of adult patients with locally advanced or metastatic nonsquamous non-small cell lung c...
Atezolizumab (a monoclonal antibody against PD-L1), which restores anticancer immunity, improved overall survival in patients with previously treated non-small-cell lung cancer and also showed clinical benefit when combined with chemotherapy as first-line treatment of non-small-cell lung cancer. IMpower...
Putative model of the insertion and duplication of an ICE copy in Mmc 95010 genome. This figure describes the events that may have led to the presence of two ICE copies in the Mmc 95010 genome. A first ICE copy may have been acquired from a donor cell by conjugation, with the subsequent...
32at an increasing frequency in the older population. Furthermore, BLC2transgenic micedevelop polyclonal follicularhyperplasiaand only after a latent period, go on to develop monoclonalimmunoblastic lymphomapresumably on the acquisition of a second “hit.”33The existence of FL lacking the t(14;18)...
(human or mouse) stimulation in the HEK 293 cell-line. In the same system, we were also able to test the selectivity to TNF by using an agonistic monoclonal antibody to TNFR1 (0.3 μg/mL) to stimulate NF-κB via the same pathway (Supplementary Fig.8). UCB-9260inhibited NF-κB ...