IC50的值越低，表示该抑制剂的抑制作用越强，因为它可以在更低的浓度抑制靶标生物分子的活性。
Small vs big: understanding the differences between small molecule drugs and biologic drugs https://www.immpressmagazine.com/small-vs-big-understanding-the-differences-between-small-molecule-drugs-and-biologic-drugs/ (2019) [Accessed 23 April 2020] Google Scholar [9] BioPharmaTrend Will biologics su...
“We found that this molecule, A485, provoked a strong increase in white blood cells, including those involved in both the adaptive and innate immune systems,” said Nikolai Jaschke, PhD, lead author of the study and a postdoctoral fellow in the lab of Andrew Wang, MD, PhD, associate...
The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. This article uses examples of successful discovery effort
These small non-coding RNAs have been implicated in synaptic plasticity and neurogenesis, as well as in neurodegeneration and psychiatric diseases.doi:10.1038/nrn3126Monica Hoyos FlightNat Rev NeurosciNature Reviews Neuroscience
Identification of a Novel Class of Small-Molecule Antiangiogenic Agents through the Screening of Combinatorial Libraries which Function by Inhibiting the Binding and Localization of Proteinase MMP2 to Integrinαvβ3. J Am Chem Soc. 2001; 123:1280–1288 PubMed CAS Google Scholar Bosslet K, ...
复旦大学 Fudan University Big-to-Small Molecule Activation Tandem with Arts of Designing Ligands 讲座论坛 0 2017-09-21 10:00 化学西楼一楼多功能厅 主讲人 Tiow-Gan Ong (王朝諺) 主讲人介绍 台湾中央研究院化学所 查看专业相关机会 化学
Cyclic di-AMP: Small molecule with big roles in bacteria. Cyclic dinucleotides are second messengers that are present in all the three domains of life, bacteria, archaea, and eukaryotes. These dinucleotides have i... S Mudgal,K Manikandan,A Mukherjee,... - 《Microbial Pathogenesis》 被引量:...
One small molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer, scientists report. In human lung cancer cells, they have shown low levels of the microRNA, miR-125a-5p, which enables the death of aberrant cells like cancer cells, ...
RCGD 423 exerts its effects by communicating with a specific molecule in the body. This molecule, called the glycoprotein 130 (Gp130) receptor, receives two very different types of signals: those that promote cartilage development in the embryo, and those that trigger chronic inflammation in the...