Large vs. Small Molecule Success Rates
26,27However, the utilization of small molecules for engineering musculoskeletal tissues has been largely overlooked. This trend is very likely to be reversed as advanced screening technologies have recently generated a large number of novel regenerative small molecule drugs, and advanced tissueengineering...
Terms for membrane transport and biological regulation are more common in small mosquitoes vs large, prior to a blood meal. Several terms for metabolic processes are higher in large mosquitoes, including organic substance, small molecule and nitrogen compound metabolic processes. Following blood meal ...
Dahl JEP, Moldowan JM, Peakman TM et al (2003) Isolation and structural proof of the large diamond molecule, cyclohexamantane (C26H30). Angew Chem Int Ed 42:2040–2044 Article CAS Google Scholar Szafert S, Gladysz JA (2003) Carbon in one dimension: structural analysis of the higher ...
The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. This article uses examples of successful discovery effort
Cancer specificity of the most cytotoxic molecule SM15 was then investigated by extending the analysis to a non tumorigenic mammary epithelial cell line (MCF10A cells) and to breast cancer MDA-MB-231 cells. HeLa and MDA-MB-231 cells were found more sensitive than MCF10A cells to the growth ...
Small molecule In pharmacology and biochemistry, asmall moleculeis anorganic compoundthat is not a polymer. Biopolymers such as nucleic acids, proteins, and polysaccharides (such as starch or cellulose) are not small molecules, although their constituent monomers—ribo- or deoxyribonucleotides, amino ...
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 2014; 40(4): 477–489S. Xiao, N. Yosef, J. Yang et al., "Small-molecule RORγt antagonists inhibit T helper 17... S Xiao,N Yosef,J Yang,... - 《Immunity》 被引量:...
and military, so polymer semiconductors have drawn increasing attention because polymers possess the attractive characteristics of the low fabrication cost offered by solution processing to be applied in the mass production of large-area electronics compared with organic small molecule semiconductors [1–4...
it is also less sensitive in number to larger aggregates (>100 nm). Conversely, single-molecule fluorescence is insensitive to single monomers and small non-β-sheet aggregates which are not ThX active and capable of measuring the size of very large aggregates at a scale of 200 × ...