In this review we will focus on proteins that modulate Smad activity, including SARA, for Smad Anchor for Receptor Activation, which functions during the initiation of signalling and on components of the ubiquitin-proteasome pathway, such as Smurf1, which can negatively regulate Smad signalling. In...
(TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently ...
liver necrosis,bile duct proliferation,and collagen accumulation.We then showed that IMB-S7 treatment markedly suppressed the TGF-β/Smad pathway in human ... N Zhang,SS Zhao,YX Zhang,... - 中国药理学报:英文版 被引量: 0发表: 2020年 ...
TGF-β family members signal through transmembrane SerThr kinase receptors that directly regulate the intracellular Smad pathway. Smads are a unique family of signal transduction molecules that can transmit signals directly from the cell surface receptors to the nucleus, where they regulate ...
(WT) mice. Moreover,miR-185depletion attenuated the osteoporotic symptoms caused by lack of estrogen in an OVX mouse model. We also found thatmiR-185regulated the expression of biglycan (Bgn), in part through which the BMP/Smad signaling pathway was also affected. These findings provide new ...
网络释义 1. 途径限制型 ...eceptor-activated Smads)或途径限制型(pathway-restricted Smad):即R- Smads,包括Smad 1、2、3、5、8、9、10。 www.haodf.com|基于 1 个网页
Exosomes derived from mesenchymal stem cells reverse EMT via TGF-β1/Smad pathway and promote repair of damaged endometrium 来自 NCBI 喜欢 0 阅读量: 209 作者:Y Yao,R Chen,G Wang,Y Zhang,F Liu 摘要: BackgroundIntrauterine adhesion (IUA) is one of the most serious complications in patients ...
The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1 Transforming growth factor (TGF)-β has been associated with renal glomerular matrix accumulation. We previously showed that Smad3 promotes COL1A2 gen...
关键词:瘢痕疙瘩;成纤维细胞;TGF-β/Smad;细胞外基质;胶原蛋白;治疗措施 Transforming growth factor beta/Smad signaling pathway and targeted therapy of keloid scars Yao Siqi, Li Wenzheng, Wang Hong Department of Burn Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101,...
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis Glioblastomas, like other solid tumors, have extensive areas of hypoxia and necrosis. The importance of hypoxia in driving tumor growth is receiving increa... B Kaur,FW Khwaja,EA Severson,... - Neuro-oncology 被...