In this review we will focus on proteins that modulate Smad activity, including SARA, for Smad Anchor for Receptor Activation, which functions during the initiation of signalling and on components of the ubiquitin-proteasome pathway, such as Smurf1, which can negatively regulate Smad signalling. In...
原名:AK2 Promotes theMigration and Invasion of Lung Adenocarcinoma by Activating TGF-β/SmadPathwayIn vitroandIn vivo 译名:AK2通过激活体内TGF-β/Smad通路促进肺腺癌的迁移和侵袭 期刊:Frontiers inPharmacology IF:5.810 发表...
(TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently ...
7.Herbertz S, et al. Clinical development of galunisertib(LY2157299 monohydrate), a small molecule inhibitor of transforming growthfactor-beta signaling pathway. Drug Des Devel Ther. 2015 Aug 10;9:4479-99. doi:10.2147/DDDT.S86621. PMID: 26309397; PMCID: PMC4539082....
[Keywords]vitamin D; lupus nephritis; miR145; TGF-β1/Smad3 signal pathway 系统性红斑狼疮(systemic lupus erythematous,SLE)是一种典型的可累及全身多系统的自身免疫性疾病。研究表明,与非SLE患者相比,SLE患者更早出现动脉粥样硬化...
2022年7月27日，清华大学免疫学研究所董晨院士团队在 Science Advances 期刊发表了题为：SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8+ T cell cytotoxic function 的研究论文。该研究系统阐述了SMAD4在调控CD8+ T淋巴细胞杀伤性功能中的作用和分子机制。在该研究中，...
“Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway” 慢性肾脏病导致的肾纤维化是终末期肾衰竭(尿毒症)的主要原因。研究表明,转化生长因子TGF-β1信号通路在肾间质纤维化过程中起到重要作用,在TGF-β刺激下,信号转运蛋白Smad3的磷酸化是整个TGF-β/Smad...
TGFβ signaling through the Smad pathway Trans forming growth factor β(TGF-β) and related cytokines regulate cell fate by signalling through two receptor serine kinases that act in sequence. Signalling by these receptors is mediated by the recently identified Smad protein fam... Joan Massaous,Ak...
The TGF-β and Wnt signaling pathways are interrelated in many cell types and tissues, and control cell functions in coordination. Here, we report that SMAD4, a downstream effector of the TGF-β signaling pathway, induces FZD4, a receptor of the Wnt sign
[9] Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC. The bone morphogenetic protein pathway is inactivated in the majority of sporadic ...