Official Full Name SMAD family member 1 Synonyms MADR1; JV4-1 Location 4q31.21 Gene Type protein-coding gene Uniprot ID Q15797 Pathway/Library others Gene Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ...
Official Full Name SMAD family member 5 Synonyms Dwfc; JV5-1 Location 5q31.1 Gene Type protein-coding gene Uniprot ID Q99717 Pathway/Library others Gene Summary The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of...
Official Full Name SMAD family member 4 Synonyms DPC4 Location 18q21.2 Gene Type protein-coding gene Uniprot ID Q13485 Pathway/Library Diabetes Related Genes Library; Tumor Invasion Related Genes Library Gene Summary This gene encodes a member of the Smad family of signal transduction proteins. Sma...
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins Authors - Hui-Li Ren View Article human WB Pediatr Surg Int Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in...
MADH5 Q99717 BC009682 >85%, as determined by Coomassie blue stained SDS-PAGE Escherichia coli His tag C-Terminus, GST tag N-Terminus The protein encoded by this gene is involved in the TGF-beta sign aling pathway that results in an inhibition of the proliferation of he matopoietic progenit...
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation. Authors - Ruichen Wang View Article rat WB Open Life Sci NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling. Aut...
SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. It is also involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and ...
On the other hand, constitutive activity of the Hippo pathway kinases large tumor suppressor kinase (LATS)1 and LATS2 promotes fibroblast quiescence in the myocardium [52], suggesting that maintaining the resting fibroblast state is an active process. 4.3. Fibroblast-specific Smad3 regulates collagen...
Full NameSMAD family member 7 Calculated Molecular Weight426 aa, 46 kDa Observed Molecular Weight45-55 kDa GenBank Accession NumberBC074819 Gene SymbolSMAD7 Gene ID (NCBI)4092 RRIDAB_2848137 ConjugateUnconjugated FormLiquid Purification MethodAntigen affinity purification ...
. The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. ...