It plays a critical role in the signaling pathway by which TGF-beta inhibits the proliferation of human hematopoietic progenitor cells. Protocols Product Specific Protocols WB protocol for SMAD5 antibody 67052-1-Ig Download protocol IHC protocol for SMAD5 antibody 67052-1-Ig Download protocol ...
Official Full Name SMAD family member 1 Synonyms MADR1; JV4-1 Location 4q31.21 Gene Type protein-coding gene Uniprot ID Q15797 Pathway/Library others Gene Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ...
Official Full Name SMAD family member 1 Synonyms MADR1; JV4-1 Location 4q31.21 Gene Type protein-coding gene Uniprot ID Q15797 Pathway/Library others Gene Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ...
Official Full Name SMAD family member 4 Synonyms DPC4 Location 18q21.2 Gene Type protein-coding gene Uniprot ID Q13485 Pathway/Library Diabetes Related Genes Library; Tumor Invasion Related Genes Library Gene Summary This gene encodes a member of the Smad family of signal transduction proteins. Sma...
JAK-STAT-SMAD pathwaysalt-sensitivity of blood pressurekidney injury.Background: High salt consumption is associated with increased cardiovascular risk and higher morbidity and mortality in salt-sensitive hypertensives than in salt-resistant normotensives. Salt sensitivity of blood pressure (SSBP) is an...
One of the functions of the TGF-β/Smad pathway during mammary gland development is to antagonize the prolactin/JAK/STAT pathway during the control of mammary gland growth, differentiation, and lactation. For instance, activation of Smad2, Smad3, and Smad4 by activin and TGF-β was found to...
The AMP-activated protein kinase (AMPK) signaling pathway, among others, regulates the expression of PEPCK and G6Pase (8). AMPK is a heterotrimeric protein, consisting of α1/2, β1/2, and γ1/2/3 subunits, that regulates glucose and fatty acid metabolism (9). Phosphorylation of Thr-17...
SMAD5 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD5 is involved in the TGF-beta signaling pathway that results in an in...
(Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds ...
Objective To explore the potential mechanism which miR-527 targeting the heparan sulfate 6-O-endosulfatase (SULF2) regulates TGF-β/SMAD signaling pathway induced epithelial-mesenchymal transition (EMT) in non-small-cell lung cancer (NSCLC). Methods 38 pairs of lung tumor biopsies and ...