The present study investigated whether hydrostatic pressure is responsible for atrial fibrosis, and addressed a potential role of the Smad pathway in this pathology. Biochemical assays were used to study regulation and expression of fibrotic factors in spontaneously hypertensive rats (SHRs) and Wistar ...
ObjectiveActivation of Smad1 signaling has recently been implicated in the development of fibrosis. The goal of the present study was to gain further insights into activation of the Smad1 pathway in fibrosis in systemic sclerosis (SSc) and to determine whether this pathway is targeted by the ...
引用本文格式 Hu TY, Einar K, Liang CX, et al. Acupotomy ameliorates knee osteoarthritis-related collagen deposition and fibrosis in rabbit skeletal muscle through the TGF-β/Smad pathway. Journal of Traditional Chinese Medical Scienc...
Aerobic exercise mitigates liver fibrosis in db/db diabetes mice by regulating transforming growth factor beta/Smad pathway Huang Chaolu, Huang Yi, Wu Changyan, Li Fangfei, Li Haiyan 中国组织工程研究 . 2025, (14): 2951 -2957 . DOI: 10.12307/2025.611 ...
Doxycycline inhibits paraquat-induced pulmonary fibrosis via TGF-β1/Smad pathway ZhouYanru PangChang ChenSilu TangXiaofang Authors Info & Affiliations Published:2019-05-20· DOI:10.3760/cma.j.issn.1001-9391.2019.05.004 342 32 0 0 1 0
A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression liver necrosis,bile duct proliferation,and collagen accumulation.We then showed that IMB-S7 treatment markedly suppressed the TGF-β/Smad pathway in human ... N Zhang,SS Zh...
Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation induced fibrosis[J] . Hiroyuki Yano,Ryoji Hamanaka,Miki Nakamura,Hideaki Sumiyoshi,Noritaka Matsuo,Hidekatsu Yoshioka.Biochemical and Biophysical Research Communications . 2012 (3)...
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin Qingzhong Hua Lu Ren Chinese Medicine(2024) Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro ...
In the present study, the effects of acupuncture on renal interstitial fibrosis (RIF) were explored in a rabbit model of CRF. Rabbits were assigned to the following five groups: sham, model, losartan potassium (Posi), acupuncture (Acup) and acupuncture+inhibitor (Acup+Inhib) groups. The CRF...
[Doxycycline inhibits paraquat-induced pulmonary fibrosis via TGF-β1/Smad pathway]. TGF-β1, a-SMA and Smad3, Smad2 proteins.#目的:探讨多西环素抑制百草枯诱导的肺纤维化的可能机制,为其临床应用提供理论依据.方法:选择人肺成纤维细胞(HFL1... YR.Zhou,C.Pang,SL.Chen,... - Zhonghua lao dong ...