NADPH oxidase isoforms have emerged as important mediators of vascular dysfunction, inflammation, and fibrosis in CKD New insights into the role of vascular calcification in the pathogenesis of CKD have led to novel therapeutic approaches, which are under preclinical and clinical development Further anima...
Furthermore, the renal expression of transforming growth factor-β1 (TGF-β1), smad2, smad3, and smad4 was down-regulated by ASPA treatment at doses of 20 and 40 mg/kg. Conclusion: ASPA possessed protective effects on renal interstitial fibrosis in UUO-induced rats. These effects may be ...
EVs were isolated from three hiPSC lines cultured under normoxia (21% O2; EV-N) or reduced oxygen concentration (hypoxia): 3% O2(EV-H3) or 5% O2(EV-H5). The anti-fibrotic activity of EVs was tested in an in vitro model of cardiac fibrosis, followed by a detailed investigation of the...
could play a crucial role in the development of the disease, the research of new molecules, capable of ameliorating both inflammation and fibrosis lesions, as PPAR-γ agonists, could represent a valid and effective therapeutic approach for the prevention and treatment of IBD and intestinal fibrosis...
to determine the effects of the GSK3 inhibitor, 6-BIO, on proximal tubular and interstitial fibroblast cells by targeting plasminogen activator inhibitor-1 (PAI-1) and connective tissue growth factor (CTGF), which play a pivotal role in progressive kidney damage and tubulo-interstitial fibrosis. ...
Endothelial inflammation plays a crucial role in vascular-related diseases, a leading cause of global mortality. Among various cellular players, endothelial progenitor cells (EPCs) emerge as non-differentiated endothelial cells circulating in the bloodst
Inflammation plays an important role in the development of heart failure (HF) after myocardial infarction (MI). Suppression of post-infarction inflammatory cascade has become a new strategy to delay or block the progression of HF. At present, there are no approved anti-inflammatory drugs used to...
MMP matrix metalloproteinase Nov nephroblastoma overexpressed protein Stat3 signal transducer and activator of transcription 3 Wisp2 wnt-induced secreted protein-2 Keywords Microarray Smad Akt TGFβ Fibrogenesis ECM CCN family CTGF Nov Renal fibrosisCited by (0)View...
In both models, the antifibrotic effects were associated with a reduction in pSMAD3 expression. Humanized AX-202 was effective in the prevention of progression of pre-established skin fibrosis in all doses tested across all endpoints (dermal thickness, myofibroblast counts, hydroxyproline content)....
The scRNAseq analysis suggests that M2-like macrophages play a crucial role in mediating the therapeutic effects of PAZ@Fe-MOF. The pseudotime trajectory of monocyte-macrophage during PAZ@Fe-MOF treatment Breast cancer is typically characterized by the infiltration of circulating monocyte-derived ...