While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older individuals. As epigenetic processes are sugges
AMuscle mass forquadriceps(QUAD),gastrocnemius(GAS),tibialis anterior(TA),plantaris(PLA),extensor digitorum longus(EDL),soleus(SOL), andtriceps brachii(TRI) was averaged across both limbs, normalized to body mass and then to 10-month-old control mice.BScatterplots and linear regressions of the ...
Since bone structure and bone mass vary with sex and age34,35,36, we hypothesised that the osteocyte-enriched transcriptome differs between the sexes and changes with age. We therefore analysed bone structure and the transcriptome of male and female mice at different ages (Fig.2a). Bone length...
baseline at 48 hours. They suggested that the majority of fluid loss and refilling takes place in the extremities to maintain the central blood volume. Consequently, change in pre- and post-HD body mass cannot be used to establish hydration of a limb or single muscle. Hence, assessing hydrati...
Vigeo; nuruk fermentation; muscle atrophy; sarcopenia; dexamethasone1. Introduction Muscles are specialized organs that enable physical movement and function, including vital actions, such as chewing and breathing [1]. Especially for older adults, maintaining adequate muscle mass is one of the most ...