Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, making “CR mimetics” of great interest. CR targets nutrient-sensing pathways centering on mTORC1. The mTORC1...
area of >200 m2,3, by the process of perilacunar remodelling, liberating calcium and phosphate in response to endocrine demands4. These features allow the osteocyte network to maintain both the structural integrity of the skeleton and mineral homeostasis. Osteocytes also have regulatory functions ...
Hemodialysis is considered to have more pronounced deleterious effects on skeletal muscle than peritoneal dialysis [2]. The consequences of HD on physical function and quality of life have been well documented [3]. In order to offset such effects, exercise interventions have been strongly recommended...
Similarly, the weight of the GA muscle per body weight in the Dex-treated group was lower than that in the control group. Conversely, the GA muscle weights per body weight of the Dex + low Vigeo-supplemented group and the Dex + high Vigeo-supplemented group significantly recovered the ...