The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.B·弗拉尼克D·L·伊顿E·H·克里斯腾森J·吴...
In this study, human single-chain antibodies (HuscFvs) that bound toexotoxin A (ETA) were generated by phage display technology using recombinant ETA, ETA-subdomains and the synthetic peptide of the ETA-catalytic site as baits for selecting ETA-bound-phages from the human-scFv phage display ...
Single-chainantibodiesselectedfromphageantibodylibrarywithsimilarbinding 系统标签: 抗体噬菌体单链抗原筛选表达水平 从噬菌体抗体库中筛选出抗原结合活性相近、表达 水平不同的单链抗体 ! 何丹 " 晁开 ! 杨慧 !! 林晴黄华木梁 # (中国科学院遗传与发育生物学研究所北京 100101 ) ( ! 西北农林科技大学生命科学...
Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery. In this review, we discuss how scFvs help improve the specificity and efficiency of drugs. Small interfering RNA (siRNA...
antibodies (intrabodies) can be readily expressed in the reducing environment of the cytoplasm and interacts with an antigen pro- tein, which results in the inhibition of the function of its target (Biocca and Cattaneo, 1995). It has been shown that monoclonal antibodies to NP protein inhibit ...
et al.Single-chain antibodies produced by phage display against the C-terminal 19 kDa region of merozoite surface protein-1 of Plasmodium yoelii reduce ... †F Chen,†Q Liu,Y Xue,... - 《Iranian Journal of Parasitology》 被引量: 2发表: 2013年 Single-chain antibodies produced by phage...
Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth. Insulin-like growth factors (IGF) I and II are potent mitogens for a variety of cancer cells. The proliferative and anti-apoptotic actions of IGF are media... SL...
COMMUNICABLE diseasesIMMUNOGLOBULINSAn abstract of the article "Single-Chain Antibodies for Viral-Based Passive Immuno-Therapy for Prion Disease: Linear Epitope Mapping and Clearance from Thalamic Injection," by Charles A. Wuertzer and colleagues is presented.Molecular Therapy...
A correction to the name of one author of the article "Fluorogen-activating single-chain antibodies for imaging cell surface proteins" is presented.Nature BiotechnologySzent-Gyorgyi, ChristopherSchmidt, Brigitte ACreeger, YehudaFisher, Gregory WZakel, Kelly LAdler, SallyFitzpatrick, James...
In wet AMD a low level of inflammation is already present, so to avoid exacerbation of disease by the therapeutic protein, we propose single-chain fragment variable antibodies (scFv, which lack the Fc domain) as a safer alternative. To investigate the feasibility of this, anti-vascular ...