SSBs have multiple roles in binding and sequestering ssDNA, detecting DNA damage, stimulating nucleases, helicases and strand-exchange proteins, activating transcription and mediating protein-protein interactions. In eukaryotes, the major SSB, replication protein A (RPA), is a heterotrimer. Here we ...
Single-Stranded DNA-Binding Proteins (SSBs) A.L. Eggler, in Encyclopedia of Genetics, 2001 Replication Owing to the intrinsic nature of replication, the process involves unwinding dsDNA to generate ssDNA. The capability of SSBs to bind ssDNA and interact functionally and physically with other p...
Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication,recombinational repair,and maintenance of genome stability.In human,the major SSB,replication protein A (RPA),is a stable heterotrimer composed of subunits of RPA1,RPA2,and RPA3,each df which is conserved not ...
Single-stranded binding proteins (SSB) bind to the outer backbone of DNA during replication. What would you predict about SSBs? A. They contain arginine and lysine residues B. They hydrolyze phosphodiester bonds C. Sequence-specific binding D. They form covalent bonds to sugars ...
Single-stranded DNA-binding proteins (SSBs) play vital roles in all aspects of DNA metabolism in all three domains of life and are characterized by the presence of one or more OB fold ssDNA-binding domains. Here, using the genetically tractable euryarchaeon Haloferax volcanii as a model, we ...
Single-Strand DNA-Binding Protein refers to a protein that binds to single-stranded DNA, playing a crucial role in protecting, processing, and regulating DNA during replication in various life forms. AI generated definition based on: Encyclopedia of Cell Biology, 2016 ...
Single-stranded DNA (ssDNA)-binding proteins (SSBs) are essential for DNA replication, recombination, and repair processes in all organisms. Sulfolobus solfataricus (S. solfataricus), a hyperthermophilic species, overexpresses its SSB (S. solfataricus SSB (SsoSSB)) to protect ssDNA during DNA ...
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as
High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein--DNA complexes. DNA in living cells is generally processed via the generation and the protection of single-stranded DNA involving the binding of ssDNA-binding proteins (SS......
Single-stranded DNA-binding proteins (SSBs) are essential for maintaining the integrity of the genome in all organisms.All processes related to DNA,such as replication,excision,repair,and recombination,require the participation of SSBs whose oligonucleotideaoligosaccharide-binding (OB)-fold domain is ...