Single-species scalingallometric scalingdrug discovery strategyclearancevolume of distribution.Aims: Multi-species Allometric Scaling (MSS) from at least three species have been used traditionally to predict human CL and Vss. Single-species Scaling (SSS) can be applied to predict these parameters from ...
Interdisciplinary teams of basic scientists, bioinformaticians, tissue engineers and clinicians should work together to connect computational approaches to outstanding biological questions, driving innovation of new regenerative therapeutics. This is a preview of subscription content,log in via an institutionto...
philippinensis (Diptera: Tephritidae) in southeast Asia: evidence for a single species hypothesis using mitochondrial DNA and wing-shape data Mark K Schutze, Matthew N Krosch, Karen F Armstrong, Toni A Chapman, Anna Englezou, Anastasija Chomič, Stephen L Cameron, Deborah Hailstones ...
Accordingly, in animal models, divalent scFvs exhibit a marked improvement in tumor targeting compared with monovalent species such as scFv and Fab because of their higher avidity and slower clearance properties rendered by their larger size [9]. To further improve their in vitro and in vivo ...
single-species allometric scaling1. We used chimeric mice (PXB mice (R)), which were repopulated with human hepatocytes, to evaluate their predictabilities of human pharmacokinetics. 查看全部>>SanohSeigoNaritomiYoichiFujimotoMamiSatoKoyaKawamura
(2015) Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver. Xenobiotica 45: 605-614.Sanoh, S., Naritomi, Y., Fujimoto, M., Sato, K., Kawamura, A., Horiguchi, A., Sugihara, K., Kotake, Y., Ohshita...
these drugs are known substrates of human CYP2C8/9/19.Human total clearance values and volumes of distribution of the 24 test compounds were extrapolated using single-species allometric scaling with experimental data from marmosets and found to be mostly comparable with the reported values.Human to...
Methods of allometric scaling have been well established in drug development to predict the dose for single dose studies for first-in-human trials from preclinical data, generally from one to three or more species such as mouse, rat, dog, or monkey. Allometric scaling is the study of body ...
Lisette Enserink.Modelling response of single-species populations to microcontaminants as a function of species size with examples for waterfleas (Daphnia magna) and cormorants (Phalacrocorax carbo).Ecological Modelling. 1996Hendriks, A.J., Enserink, E.L., 1996. Modelling response of single-...
In addition, the physiological model was compared with multiple-species allometry for three proteins. Results: In general, the novel physiological model is superior to the derived allometric methods. Overall, the physiological model produced a predicted CLH value with levels of accuracy of 100% ...