Manipulation of the murine genome has made small animal models standard surrogates for better understanding the healthy and diseased human cardiovascular system. It has therefore become increasingly important to understand how results scale from mouse to human. This noninvasive methodology provides the ...
Changes in plasma and erythrocyte phospholipid compositions were compared with archival human data from over 100 clinical trials. At all three doses, dietary ALA and EPA increased mouse EPA PL levels to a greater extent (3–4 fold) than that observed in humans, but had minimal impact on ...
Schematic and picture of the MSI model. FEM confirming that MSIs recreate human levels of mechanical stress in the mouse. Sx refers to the mechanical stress in thexdirection.d, Trichrome staining of FBR capsules in the human
Metabolic scaling law for mouse fetal and placental weight Human birth weight does not scale linearly with the weight of the placenta: placental mass (PM) is proportional to the fetal mass (FM) raised to the scalin... M Gasperowicz,M Yampolsky,Salafia, C.M. - 《Placenta》 被引量: 4...
The EC50 of MSD114 in human neuroblastoma cells was 20nM. When given to transgenic mice, Ab42 levels were lowered by 50-90% while Ab40 levels decreased only by 20%. The metabolic stability of this compound across 5 species (mouse, rat, dog, cynomolgous monkey, human) was determined ...
Methods of allometric scaling have been well established in drug development to predict the dose for single dose studies for first-in-human trials from preclinical data, generally from one to three or more species such as mouse, rat, dog, or monkey. Allometric scaling is the study of body ...
An equation that scaled τ with body mass included a constant (c) and an allometric scaling parameter (n), and the best model included n, Thr, and two c. The final model provided accurate predictions for 58 out of 61 dive profiles for pig, hamster, rat, and mouse. Thus, body mass ...
On the Scaling of Tooth Size in Mammals We must establish the allometric regularities of functional scalingin interspecific, "mouse-to elephant" plots in order to provide criteria for the recognition of special adaptations unrelated to the requirements of size. The qualitative... SJ Gould - 《Amer...
PK and blood glucose parameters were scaled by allometric principles using body weight as a scaling factor along with an estimation of the parameter exponents. Biomarker and tumor growth parameters were extrapolated from mouse to human using the body weight ratio as scaling factor.#The allometric PK...
2.P.28 Preclinical drug metabolism studies in rat, mouse, dog and monkey with allometric scaling for CP-340,868, a novel squalene synthetase inhibitorPublication » 2.P.28 Preclinical drug metabolism studies in rat, mouse, dog and monkey with allometric scaling for CP340,868, a novel ...