Evaluate human PK prediction of compound LY based on allometric scaling with three speciesCLINICAL PHARMACOLOGY AND THERAPEUTICS -ST LOUIS-S.AndersonMahadevan
Encyclopedia Related to allometric:allometric growth al·lom·e·try (ə-lŏm′ĭ-trē) n. 1.The disproportionate growth of a part or parts of an organism as the organism changes in size. 2.The study of such growth. al′lo·met′ric(ăl′ə-mĕt′rĭk)adj. ...
There is an exceptional case in which Shinozaki’s pipe model predictions should not explain that the allometric scaling exponent between foliage mass and stem diameter at the crown base is bigger than 2 empirically. This study proposes an allometric scaling model with components f and b, which ...
Allometric scaling laws relate structure or function between species of vastly different sizes. They have rarely been derived for hemodynamic parameters known to affect the cardiovascular system, e.g., wall shear stress (WSS). This work describes noninvasive methods to quantify and determine a ...
摘要: An allometric scaling law between the metabolic rate of the total barks of a plant and its total bark mass is proposed, the scaling exponent is proved to be 2/3 for mature plants.DOI: 10.1088/1742-6596/96/1/012179 被引量: 1 ...
Although most physiological traits scale allometrically in unitary organisms, it has been hypothesized that modularity allows for isometric scaling in colonial modular taxa. Isometry would allow increases in size without functional constraints, and is thought to be of central importance to the success of...
mass and petiole mass of 93 temperate woody species vary with leaf habit, leaf form and altitude 1. The allometric scaling relationship between lamina and lamina support has rarely been examined, such that its significance to plant life-history strategies has not been fully explored and understood...
with 21 orders of magnitude variation between their body mass- from Bacteria to Elephas maximumand Struthio camelus.The study shows the existence of a linear relationship between the total metabolic energy perlifespan Pls (kJ), and the body mass M (kg) of all species from type: Pls=AlsM ...
Here we investigate the allometric scaling of the hematopoietic system in a large group of mammalian species using reticulocyte counts as a marker of the active stem cell pool. Our model predicts that the total number of active stem cells, in an adult mammal, scales with body mass with the ...
Conclusions For propofol, allometric scaling has proved to be valuable for cross species extrapolation. Furthermore, the use of the allometric equation between adults and children seems to be an adequate tool for the development of rational dosing schemes for children of varying body weights, and ...