we compared the accuracy of three approaches to predict the apparent clearance (CL/ F ) and apparent volume of distribution ( V d / F ) for 15 monoclonal antibodies in humans (1) allometric scaling from cynomolgus monkeys; (2) geometric mean of reported values in humans; (3) estimation fr...
This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling. The method of calculation of injection volume of parenteral formulation based on human equivalent dose is also briefed. 展开 ...