Iteratively, our algorithm randomly sampled cells from each donor in each cluster K without replacement until the number of cells in the newly sampled cluster, k, exceeded x (nk > x). For cases where NK < x, the number of sampled cells is equal to the cluster size (nk =...
L. Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic–pituitary–adrenal axis activity of male and female rats. J. Neuroendocrinol. 16, 989–998 (2004). Article CAS PubMed Google Scholar Li, F. et al. Distinct ...
a two-dimensional UMAP of cluster assignments, and the fraction of fetal cells within each cluster (aii). The absolute number of cells across fetal or adult conditions inb—a bidirectional bar chart shows stage bias of each cluster. Differential...
restructured regulatory interactions to dysregulate enhancer activity and gene expression critical to erythroid lineage differentiation. Furthermore, as mutations in Down syndrome display a signature of oxidative stress4,5, we validated both increased mitochondrial mass and oxidative stress in Down syndrome, ...
Cells falling between FACS gates are excluded from the chart. CD71 + 41 + MEP are significantly less frequent, constituting 5.1 ± 0.6 % of total MEP (mean ± SEM, P <0.0001). g Expression of CD42 in the three MEP subfractions. CD42 expression is restricted to a minority (20.7 ± ...
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The institutional review board (IRB) of Johns Hopkins University approved retrospective chart analysis of patients ≤21 years of age treated at our institution for hematologic malignancies with myeloablative matched related donor BMT using PTCy along with contemporary controls receiving historical standard GV...
Author Correction: Engineering of high-precision base editors for site-specific single nucleotide replacement.The original version of this Article contained an error in Figure 5. In the panel c, the right bar chart was inadvertently ... Junjie,Tan,Fei,... - 《Nature Communications》 被引量: ...
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1,00
(GWAS) loci relevant for blood cell traits and evaluated their activity in HSCs. We found that HSCs from branch 1 were significantly enriched for cells with increased accessibility of GWAS SNPs relevant to white blood cell count, whereas HSCs from branch 2 were significantly enriched for cells ...