Fig. 1: Clustering and dominant immune cells associated with neoadjuvant response. AFlow chart of the overall study design (Figure created with biorender.com.). CD45+immune cells derived from tumor tissues (T) and five immune-relevant sites (nearest non-cancer tissues (N), regional draining lym...
The global population is increasing, with a predicted demand for 1250 million tonnes of animal-derived protein by 2050, which will be difficult to meet. Single-cell protein (SCP) offers a sustainable solution. This review covers SCP production mechanisms
presence of inhibitors or competitors (such as ACE2)55or screening for orthologue cross-reactivity for testing in animal models62. More generally, this methodology could be used for antibody discovery outside of the context of infectious diseases, for example, by harnessing (humanized) mice for th...
Fig. 4 The diversity of immune cells in EAU retinas. (A) UMAP plots and pie charts of immune cell clusters in control and EAU retinas. The left pie chart shows there are few immune cells in control retinas while the right pie chart shows that Th1 cell is the predominant class of T he...
EE2 is used in oral contraceptive formulations and hormone replacement therapy, and has been previously shown to be of environmental concern because of its effects on fish reproduction and sexual development at extremely low concentrations (reviewed in Sumpter and Jobling, 2013). Along with EE2, ...
The bar chart at the top of the heat map shows the intensity of cell communication for each cell type (Figure 7A). The ESCs exhibited most of the outgoing signals and CD8+ T cells received most of the incoming signals at 4.5 and 5.5 dpc (Figure 7A). The uNK cells, B cells, and ...
grouped Armenian and Syrian hamster IgG monoclonal antibodies according to their reactivity with a panel of mouse anti-hamster IgG mAbs. A table of the hamster IgG groups, Reactivity of Mouse Anti-Hamster Ig mAbs, may be viewed at http://www.bdbiosciences.com/documents/hamster_...
grouped Armenian and Syrian hamster IgG monoclonal antibodies according to their reactivity with a panel of mouse anti-hamster IgG mAbs. A table of the hamster IgG groups, Reactivity of Mouse Anti-Hamster Ig mAbs, may be viewed at http://www.bdbiosciences.com/documents/hamster_...
Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs) and is the main target for vaccine design. Here, we first investigate the contribution of the stalk and heptad repeat 1-C (HR1C) regions to GP metastability. Specific stalk and HR1Cmodifications in a...
and Omicron BA.1 (KD = 1 nM) variants (Fig.1a). Binding to the RBDs of the Kappa (KD = 103 nM), Delta (KD = 63 nM) and Lambda (KD = 467 nM) variants was greatly reduced (Fig.1a). In addition, R1-32 showed some cross reactivity by binding to ...