Toll IL-1R8/single Ig IL-1- related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by gd T cells. J. Immunol. 191: 3337-3346.Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, et al. Toll IL-1R8/single Ig IL...
IG_V_gene Example minimal GTF row used by Cell Ranger V(D)J 14 havana CDS 21621904 21621946 . + 0 transcript_id "ENST00000542354"; gene_name "TRAV1-1"; transcript_biotype "TR_V_gene"; Reference package format cellranger mkvdjrefcreates a directory whose named is specified by the--geno...
Similar to Change-O23, Dandelion re-annotates V(D)J contigs using igblastn25with reference sequences contained in the international ImMunoGeneTics information system (IMGT) database26. blastn is also used to check theDandJgenes separately (same settings as igblastn25. The additional blastn ste...
42 HSCs express both Il-11ra1, a receptor belonging to the interleukin (IL)-6 family, and its ligand Il-11, constituting a previously unknown autocrine signal which stimulates the activation of STAT3 and ERK, as well as cytokine secretion.42 Analysis of HSC gene expression also revealed ...
8B, arrowhead), which has been related to M2 polarization [20], and low scores of immune response-related signatures (Fig. 4C, white arrowheads), while cluster 2 expressed high levels of proinflammatory chemokines, such as CXCL9 and CXCL10, the proinflammatory cytokine IL1B (Supplementary Fig...
gondii infection can affect the expression levels of some inhibitory molecules (leukocyte immunoglobulin-like receptor B4, inhibitory receptor T-cell immunoglobulin and mucin domain 3, and B7 homolog 4, etc.) in these immune cells and then regulate the expression of functional molecules (IL-10, ...
This discovery offers a potential novel therapeutic target for BPH that operates independently of androgen receptor signaling. Furthermore, in this study, we aimed to clarify the correlation between glandular and stromal nodular formation by utilizing pseudo-time trajectory analysis on BE5 cells. We ...
Furthermore, novel cell markers, transcription factors, and ligand-receptor pairs are identified with potential functional regulations in maintaining the homeostasis of human cells among tissues. Conclusions The adult human cell atlas reveals the inter- and intra-organ heterogeneity of cell characteristics...
We also identified hematopoietic progenitor cells (HPCs) by the stem cell-related genes myb, npm1a, and csf1rb in zebrafish, and npm1a, myb, and kita in Chinese tongue sole. B cells were characterized by blnk, btk, flt3, and igll1-like in bamboo shark, cd79a and pax5 in the two ...
4D). CXCL10, CCL2, CCL8, PD-L1, IL4I1, PFKFB3, TGFB1 and CD44 genes exhibited higherlevels (p < 0.05) in IFN_TAMs than LA_TAMs, while the difference of PD-L2 level was not significant (Fig. 4E). While fatty acid-related metabolic pathways, such as arachidonic acid ...