Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and 2 are differentially expressed in prostate cancer. PLoS ONE. 2012;7:e50953. CAS PubMed Central PubMed Google Scholar Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update....
Insulin family members have significant roles as bioactive substances. Insulin controls blood glucose levels and insulin-like growth factor (IGF) influences growth, differentiation and survival of cells. IGF signals are transduced through the type I IGF receptor (IGF1R), which is closely related to ...
Receptor de IGF-I IGFBP: Insulin-like growth factor binding protein IL: Interleukin IUGR: Intrauterine growth restriction LH: Luteinizing hormone LS: Laron syndrome MAPK: Mitogen-activated protein kinase MDA: Malon-dialdehyde NO: Nitric oxide NSILA: Non-suppressible insulin-like activit...
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4) ArticleOpen access30 January 2023 Introduction The insulin/IGF superfamily of hormones includes insulin and insulin-like growth factors-1 and −2 (IGF-1 and 2), three isoforms of relaxin (RLN1, 2, and 3) ...
Insulin-like growth factor-1 (IGF-1) enhances developmental competence of cat embryos cultured singly by modulating the expression of its receptor (IGF-1R) and reducing developmental block Chommanart Thongkittidilok, Theerawat Tharasanit, Thanida Sananmuang, Sirirak Buarpung, Mongkol Techakumphu ...
Insulin-like growth factor-1 receptor inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors Triple-negative breast cancers (TNBC) are an aggressive disease subtype which unlike other subtypes lack an effective targeted therapy. Inhibitors of the insullin-like growth fac...
Hellawell, G. O., Turner, G. D., Davies, D. R., Poulsom, R., Brewster, S. F., & Macaulay, V. M. (2002). Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.Cancer Research, 62, 2942...
(EGF) receptor family, activates the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway, leading to phosphorylation of IκB in breast cancer cells.16 Then, phosphorylated IκB undergoes ubiquitylation/degradation and the released NF-κB heterodimer is transported to the nucleus for transcriptional ...
Adams et al., “Structure and function of the type 1 insulin-like growth factor receptor”, Cell Mol Life Sci. Jul. 2000;57(7):1050-93. McKern et al., “Crystallization of the first three domains of the human insulin-like growth factor-1 receptor”, Protein Sci. Dec. 1997;6(12)...
We identified RACK1, a WD repeat family member and a Gbeta homologue, and demonstrated that RACK1 interacts with the IGF-IR but not with the closely related insulin receptor (IR). In several types of mammalian cells, RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in...