Receptor, IGF Type 1Antineoplastic AgentsThere is abundant in vitro, animal and epidemiologic evidence to suggest that the Insulin-Like Growth Factor (IGF) family is a multi-component network of molecules which is involved in the regulation of both physiological and pathological growth processes in ...
上海玉博生物科技有限公司 主要致力于“IGF-I( Insulin-like Growth Factor-I ) 胰岛素样生长因子-I(抗原) yb-0014P”的生产销售。多年的“IGF-I( Insulin-like Growth Factor-I ) 胰岛素样生长因子-I(抗原) yb-0014P”生产与销售的经验,与各行业新老用户建立
Insulin and IGFs have been found in animal species ranging from insects to humans22. Recently, we extended the scope of the insulin/IGF family of hormones by identifying viral insulin/IGF-1 like peptides (VILPs) in four members of the Iridoviridae family of double-stranded-DNA viruses23. W...
Furthermore, addition of IGF-1 in vitro to differentiated muscle cells promotes myotube hypertrophy (10, 11, 12), supporting the idea that IGF-1 is sufficient to induce hypertrophy. The binding of IGF-1 to its receptor triggers the activation of phosphatidylinositol 3-kinase (PI3K). PI3K ...
Insulin-like growth factor-1 (IGF-1) enhances developmental competence of cat embryos cultured singly by modulating the expression of its receptor (IGF-1R) and reducing developmental block Chommanart Thongkittidilok, Theerawat Tharasanit, Thanida Sananmuang, Sirirak Buarpung, Mongkol Techakumphu ...
Insulin family members have significant roles as bioactive substances. Insulin controls blood glucose levels and insulin-like growth factor (IGF) influences growth, differentiation and survival of cells. IGF signals are transduced through the type I IGF receptor (IGF1R), which is closely related to ...
Annenkov, A. (2012). Insulin-like Growth Factor Receptor Type I (IGF1R) Signaling and Inflammation. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_326
Receptor de IGF-I IGFBP: Insulin-like growth factor binding protein IL: Interleukin IUGR: Intrauterine growth restriction LH: Luteinizing hormone LS: Laron syndrome MAPK: Mitogen-activated protein kinase MDA: Malon-dialdehyde NO: Nitric oxide NSILA: Non-suppressible insulin-like activit...
The insulin-like growth factor receptor (IGF-IR) has been implicated in a number of human tumors, including breast cancer. Data from human breast tumors has demonstrated that IGF-IR is over-expressed and hyper-phosphorylated. Additionally, microarray analysis has shown that IGF-I treatment of MCF...
(EGF) receptor family, activates the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway, leading to phosphorylation of IκB in breast cancer cells.16 Then, phosphorylated IκB undergoes ubiquitylation/degradation and the released NF-κB heterodimer is transported to the nucleus for transcriptional ...