We set out to investigate active signalling pathways in the human EPI, reasoning that as in the mouse, identifying these pathways in embryos would inform strategies for maintaining pluripotent hESCs in physiologically relevant conditions. Here we mine available datasets to identify receptor-ligand pairs ...
100% homologous with bovine and porcine proteins. Low levels of IGF1 have been linked to Alzheimer's disease. IGF1 is processed from a precursor, bound by a specific receptor, and secreted. Defects in the IGF1 gene are a cause of insulin-like growth factor 1 deficiency and several ...
Manipulating the activity of olfactory receptor neurons (ORNs) affects the development of glioma. Mechanistically, olfaction excites mitral and tufted (M/T) cells, which receive sensory information from ORNs and release insulin-like growth factor 1 (IGF1) in an activity-dependent manner. Specific ...
IGF-I actions are mediated through its binding to several cell-membrane receptors and the IGF-I domain responsible for the receptor binding is the bioactive mature IGF-I peptide, which is derived after the posttranslational cleavage of the pro-IGF-I isoforms and the removal of their carboxy-...
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought. Moreover, it has become ...
Their bioactivity contributes to inhibit the ligand of Insulin-Like Growth Factor I Receptor (Igf-1r) binding-region to Igf-1 protein. To elucidate the inhibiton of Igf-1 expression and proliferating of Rattus norvegicus strain wistar adipose cell using black tea solution. The research used Rattus...
99mTc-CCND1-Peptide nucleic acid (PNA)-IGF1 peptide chimeras (99mTc-WT4185) is a 99mTc-peptide-PNA-peptide chimera that was developed as a gene expression agent for gamma planar/single photon emission computed tomography (SPECT) imaging of breast cancer (1, 2). 99mTc-WT4185 is a radiohybri...
In binding experiments to crude Gilthead Seabream brain homogenate, using human (h) IGF-I as a ligand, the respective IC50 value of hIGF1 was about fourfold lower than that of Gilthead Seabream IGF-1. Recombinant Gilthead Seabream IGF-1 exhibited mitogenic activity in a mouse mammary ...
The Regulation of IGF-1 Gene Transcription and Splicing during Development and Aging. Front. Endocrinol. 2013, 4, 39. [Google Scholar] [CrossRef] Rowzee, A.M.; Lazzarino, D.A.; Rota, L.; Sun, Z.; Wood, T.L. IGF ligand and receptor regulation of mammary development. J. Mammary ...
Moreover, functional anno- tations of predicted miRNA targets in the differentiation and the TNF-α treatment group include RNA degradation and neuroactive ligand-receptor interaction (Additional files 2B,E; 4A,B). Predicted targets of TNF-α-regulated miRNAs are enriched in KEGG pathways such as ...