Single-cell genomics meets human genetics In this Review, the authors describe the emerging field of single-cell genetics, which lies at the intersection of single-cell genomics and human genetics. They review the first single-cell expression quantitative trait loci studies, which combine single-cell...
Single-cell genomics meets human genetics Article 21 April 2023 Quantitative single-cell proteomics as a tool to characterize cellular hierarchies Article Open access 07 June 2021 Data availability The CNGB Nucleotide Sequence Archive accession number is CNP0000325 (https://db.cngb.org/search/?q...
Cellular heterogeneity is revolutionizing the way to study, monitor and dissect complex diseases. This has been possible with the technological and computational advances associated to single-cell genomics and epigenomics. Deeper understanding of cell-to-cell variation and its impact on tissue function wi...
Single-cell omics is transforming our understanding of cell biology and disease, yet the systems-level analysis and interpretation of single-cell data faces many challenges. In this Perspective, we describe the impact that fundamental concepts from stati
datasets with hundreds or thousands of cells. Comprehensive simulations suggest that CellPhy is more robust to single-cell genomics errors and outperforms state-of-the-art methods under realistic scenarios, both in accuracy and speed. CellPhy is freely available athttps://github.com/amkozlov/cell...
The cell suspension was loaded into chips of a Chromium Next GEM Single Cell 3′ Reagent Kit v3.1 (PN-1000128, 10× Genomics, Pleasanton, CA, USA) and subjected to a Chromium Single Cell Controller (10× Genomics, USA) to generate single-cell GEM. Then, a primer containing Illumina Tru...
SNVs; Macaca; macaques; comparative genomics; genetic diversity; biomedical applications Graphical Abstract1. Introduction Macaca is of great importance in evolutionary and biomedical research, belonging to the Cercopithecidae family, a diverse and widespread primate group that contains 23 extant species...
Variant to function mapping at single-cell resolution through network propagation Nat Biotechnol, 40 (2022), pp. 1644-1653 Google Scholar 76 A.S.E. Cuomo, A. Nathan, S. Raychaudhuri, D.G. MacArthur, J.E. Powell Single-cell genomics meets human genetics Nat Rev Genet, 24 (2023), pp....
Single Cell Techonoly Single-Modality Multimodality Spatial Transcriptomic [2022 Nature Methods] Museum of spatial transcriptomics [paper] Course [CSCI 1850 Deep Learning in Genomics], Brown University [Machine Learning in Genomics: Dissecting Human Disease Circuitry], MIT [ANALYSIS OF SINGLE CELL RNA-SE...
Single cell analysis has been beyond the capabilities of ‘Omics’ technologies. This is rapidly changing with the recent examples of single cell genomics, transcriptomics, proteomics, and metabolomics. Single cell data helps to address the cellular heterogeneity arising from stochastic expression of ...