Single-cell atlas of the human brain vasculature across development, adulthood and disease Thomas Wälchli, Moheb Ghobrial, Marc Schwab, Shigeki Takada, Hang Zhong, Samuel Suntharalingham, Sandra Vetiska, Daymé Rodrigues Gonzalez, Ruilin Wu, Hubert Rehrauer, Anuroopa Dinesh, Kai...
et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature 554, 475–480 (2018). CAS PubMed ADS Google Scholar Montagne, A. et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296–302 (2015). CAS PubMed PubMed Central Google ...
Single-cell atlas of the human brain vasculature across development, adulthood and diseasedoi:10.1038/s41586-024-07493-yA broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular ...
To do so, they used samples from 30 different brain regions to draw out and build up, cell by cell, a new atlas. Altogether, the final map was composed of a 4.2 million cellular atlas of the adult primate brain. “Our data, which we have made open and available to the ...
Here, we performed single-cell RNA sequencing of 606,380 freshly isolated endothelial, perivascular and other tissue-derived cells from 117 samples, from 68 human fetuses and adult patients to construct a molecular atlas of the developing fetal, adult control and diseased human brain v...
A comparative atlas of single-cell chromatin accessibility in the human brain 发表期刊和时间:Science,13 October 2023 Lab:Bing Ren, 实验室正在研究正常和癌症细胞的基因调节机制,与路德维希研究所和加州大学合作密切。 摘要:探索了三名成年人42个大脑区域110万个细胞的开放染色质景观。整合这些数据揭示了107种...
Figure 1. Gastric Muscle Immune Cell Atlas from Healthy Volunteers and Patients with Idiopathic Gastroparesis (A) Schematic representing the dissociation and isolation of CD45+ cells from mucosa deprived muscle layer for scRNA sequencing. (B) Immunohistochemistry showing the distribution of CD45+ cells...
However, there are limited data on the unique features and functions of fetal mucosal immune cells. To address this gap, we integrated several single-cell ribonucleic acid sequencing datasets of the human small intestine (SI) to create an SI transcriptional atlas throughout the human life span, ...
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing increasing depth and resolution to maps of huma...
Now a multinational team of scientists led by experts at Cincinnati Children's has developed an "atlas" of human fetal brain development so detailed that it details growth steps all the way down to changes occurring at the single-cell level. Details were published Nov. 30 inNature. ...