Mesenchymal stem cells (MSCsTransdifferentiationPericytesBrain injuryCancer stem cellsMesenchymal stem cells (MSCs) communicate and interact with nervous system during brain development, injuries, and tumor formation. Several in vitro studies showed MSCs can transdifferentiate into neurons, by induction using...
Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. Despite these advances, tumor resistance to che
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell field. In CML, the acquisition of the fusion tyrosine kinase BCR–ABL1 in a haematopoi
Their differentiation pathways are under the control of different cytokines, namely Stem Cell Factor for mast cells and Interleukin-3 for basophils. While mast cells are tissue-resident elements, basophils are found exclusively in the bloodstream. In contrast to basophils, mast cells are heterogeneous...
Here, I propose that cancer stem cells (CSCs) would be equivalent to para-embryonic stem cells (p-ESCs), derived from adult cells de-re-programmed to a ground state. p-ESCs would differ from ESCs by the absence of genomic homeostasis. A p-ESC would constitute the cancer cell of origin...
Microscopic images show a non-small cell breast cancer, left, and small cell neuroendocrine breast cancer, right. Small cell neuroendocrine cancers typically feature smaller cells and larger nuclei in relation to cell size. Credit: Cancer Cell/UCLA Broad Stem Cell Research Center ...
On the origin and destination of cancer stem cells: A conceptual evaluation Despite remaining uncertainties and ongoing research it is possible to draw up a model for the role of (cancer) stem cells in both the initiation and progr... AVD Stolpe - 《American Journal of Cancer Research》 被引...
Cui J, Zhao S, Li Y et al (2021) Regulated cell death: discovery, features and implications for neurodegenerative diseases. Cell Commun Signal 19:120 PubMedPubMed CentralGoogle Scholar Peng F, Liao M, Qin R et al (2022) Regulated cell death (RCD) in cancer: key pathways and targeted ...
The NCRM-1 cell line, derived from CD34+ cord blood cells, was acquired from Rutgers University and Sampled, New Jersey, USA. Cells were maintained in mTeSR1 (Stem Cell Technologies) on Matrigel (Corning). They were passaged to a single cell Human cornea organoids (HCOs) deposit ECM ...
which are pigmentssent to other skin cells to shield them from harmful ultraviolet light. A lack of functioning melanocytes causes awide range of skin conditions, including skin cancer and vitiligo, an autoimmune condition in which the body attacks melanocytes and causes patches of depigmented skin...