Kadereit, By Suzanne
Research Highlights14 Jan 2025Nature Reviews Cancer Volume: 25, P: 77 Single-cell analysis dissects heterogeneity of leukemias with complex karyotypes Chromosomal instability plays a crucial part in tumor progression, shaping cancer cell phenotypes and driving treatment resistance. We harnessed two single...
The termcancer stem cell(CSC) is an operational term used to describe the small percentage of cells within asolid tumorcapable of unregulated self-renewal, leading to continued tumor growth, as well as of the generation of partially differentiatedprogenitor cells[1–3]. As proposed in the stem ...
CANCER STEM CELL A cancer cell that has the potential to transfer disease or to form tumours following transplantation. Cancer stem cells have the potential to self-renew, forming additional tumorigenic cancer cells of similar phenotype, and to give rise to phenotypically diverse cancer cells with ...
解析:肿瘤干细胞Cancer Stem Cell,CSC http://www.liankebio.com/article-information_Newsletter-842.html 作者: 联科生物 发布日期:2015-02-15 08:00 肿瘤干细胞是肿瘤中一小群具有自我更新能力,并能产生异质性肿瘤细胞的细胞。肿瘤干细胞假说最先是由Mackillop于1983年提出,他认为在所有的肿瘤中都可能存在着一...
研究发现,线粒体脂肪酸氧化(FAO)对HSCs的自我更新至关重要,然而线粒体代谢如何调控HSC命运背后的机制仍不清楚。近日,研究人员在Cell Stem Cell上发表研究成果,报道了线粒体NADPH-胆固醇轴在调控细胞外囊泡发生和HSC命运中的重要作用。...
The two broad types of mammalian stem cells are: embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in adult tissues. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult ...
【肿瘤干细胞理论 The Cancer Stem Cell Theory】肿瘤干细胞对肿瘤的存活、增殖、转移及复发有着重要作用。从本质上讲,肿瘤干细胞通过自我更新和无限增殖维持着肿瘤细胞群的生命力;肿瘤干细胞的运动和迁徙能力又使肿瘤细胞的转移成为可能;肿瘤干细胞可以长时间处于休眠状态并具有多种耐药分子而对杀伤肿瘤细胞的外界理化...
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
近日,来自美国希望之城国家医疗中心血液学与造血细胞移植科的Jianhua Yu与Michael A. Caligiuri共同在Cell Stem Cell期刊发表题为Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer(人类抗PSCA CAR...