Therefore, the main aim of this study was to investigate the gene expression levels and possible correlation between PKCε, TPD52, miR-124 and KLF14 to improve understanding of their contribution in the development of brain cancer and neoplasm lesions. A potential advantage of this blood-based ...
By decreasing the oxygen-carrying capacity of the blood, may result in hypoxia and may have a negative influence on the outcome of radiotherapy for various , even for small not normally assumed to be hypoxic. In addition, also has a negative effect on the quality of life of patients, as ...
The correlation between other indexes and the growth of pulmonary nodules was not statistically significant (Pcd44v6 = 0.104;PEGFR = 0.337; PMDM2 = 0.49; PTGF-β1 = 0.141). In the subgroup of patients with non-invasive lung cancer, there was a correlation between VEGF ...
significant potential, especially with the development of small-molecule inhibitors for IDO1, TDO, and other key enzymes. These inhibitors disrupt the immunosuppressive signals within the TME, potentially restoring effective anti-tumor immune responses. Recently, IDO1 inhibitors have been tested in clinic...
[1,57,58,59]. These sources provide the necessary intake to maintain adequate Trp levels essential for various biological functions [60,61,62]. Upon ingestion, Trp is absorbed in the intestines and transported through the blood to various tissues [63,64,65,66]. Key transporters, such as ...
There was no significant difference in either overall survival (OS) or progression- free survival (PFS) according to E-cadherin expression (P > 0.05). Although the OS rates were not affected by N-cadherin expression levels (P = 0.138), PFS increased in the low N-cadherin expression group ...
Lung cancer remains the leading cause of cancer death. Treatment with immune checkpoint inhibitor (ICI) alone or combination with chemotherapy served as first-line therapy in non-small cell lung cancer (NSCLC). However, only 20–50% of NSCLC patients res
Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs are critically involved in shaping the structure and function of...
Manabu Ogita1, Takayuki Yokoyama1, Atsushi Amano2 and Hiroyuki Daida1 An equation that accurately estimates the glomerular filtration rate (GFR) in the Japanese population has been proposed; however, the prognostic significance of estimated GFR (eGFR) defined according to this equation has not been...
Results: In the ICM group, there were more patients with hypertension and diabetes, and patients had higher levels of HbA1c, blood urea nitrogen, creatinine and uric acid, and lower levels of eGFR and bFGF than patients in the control group (P < 0.05). The 12-month endpoint event rate ...