Patients without overexpression had a higher prevalence of tumors with a low mitotic rate (31% vs. 0%, P = 0.049). Neurofibromatosis was more prevalent in patients with EGFR overexpression (75% vs. 42%, P = 0.007). Five year disease free survival (mean 30.1 vs. 17.4 months, P = ...
CONCLUSIONS: Low eGFR at baseline predicts poor functional outcome and all-cause mortality at 3-month in acute ICH patients. Also, high cystatin C was associated with increased risk of mortality but not with poor functional outcome. 2016 S. Karger AG, Basel. 展开 关键词: Estimated glomerular ...
Objective:To evaluate the significance of the expressions of nuclear factor-κB(NF-κB),Cyclin D1,C-Src and EGFR in esophageal cancer.Methods:Immunohistochemistry(S-P)method was employed to determine the expressions of NF-κB,Cyclin D1,C-Src and EGFR in esophageal carcinogenesis.Results:NF-κB...
Manabu Ogita1, Takayuki Yokoyama1, Atsushi Amano2 and Hiroyuki Daida1 An equation that accurately estimates the glomerular filtration rate (GFR) in the Japanese population has been proposed; however, the prognostic significance of estimated GFR (eGFR) defined according to this equation has not been...
The correlation between other indexes and the growth of pulmonary nodules was not statistically significant (Pcd44v6 = 0.104;PEGFR = 0.337; PMDM2 = 0.49; PTGF-β1 = 0.141). In the subgroup of patients with non-invasive lung cancer, there was a correlation between VEGF ...
Previous studies have suggested that EGFR plays a vital role in the development and progression of NPC [5]. While several biomarkers have been employed in the determination of the prognosis and metastasis of NPC patients, the molecular mechanisms regarding the development and progression of NPC ...
Further exploration revealed that KDELR, as a receptor for ER proteins secreted at the cell membrane, has its own downstream signaling network, including trans-activation of the EGFR-STAT3 signaling pathway12. Moreover, accumulating evidence have shown that KDELRs are associated with the development...
NT-proBNP, troponin and eGFR median were 2223 pg/mL [2054–2822], 51 ng/l [34–99] and 61 ml/min [50–70], respectively. All patients were classified stage I or II of Gillmore as well as Grogan staging systems. All biopsies showed liver fibrosis with 4 (57 %) scoring F1 and 3...
Metastatic disease was detected in the liver of 11 patients (13.6%) and in the brain of 22 patients (27.2%). With regards to disease staging, 19 patients (23.5%) were at stage III, 51 (63.0%) were at stage IV, and 11 (13.6%) showed postoperative recurrence. An EGFR mutation ...
SK-Mel-28 and A375 cells in a TDO-dependent manner, resulting in a highly proliferative and metastatic phenotype [214]. In LC A549 and Lewis cells, CAFs produce Kyn and upregulate AHR expression to activate AKT and ERK signals, facilitating cell proliferation and resistance to EGFR TKIs [195...