The IκB kinase (IKK) complex is fundamental to signaling to NF-κB. The large apparent molecular weight of the complex has led to a hunt for components of the complex in addition to IKKα, IKKβ and the regulatory subunit NEMO. Yet of the numerous interacting proteins identified none have...
Signaling to NF-kappaB by Toll-like receptors. 来自 国家科技图书文献中心 喜欢 0 阅读量: 286 作者: T Kawai,S Akira 展开 摘要: Innate immunity is the first line of defense against invading pathogens. A family of Toll-like receptors (TLRs) acts as primary sensors that detect a wide...
• NF-κB signaling is involved in ammonia-induced bioenergetics regulation. Abstract Hyperammonemia is very toxic to the brain, leading to inflammation, disruption of brain cellular energy metabolism and cognitive function. However, the underlying mechanism(s) for these impairments is still not fully...
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Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 2007; 13: 460–469. 36 Chang M, Jin W, Sun SC. Peli1 facilitates TRIF-dependent Toll-like receptor sig- naling and proinflammatory cytokine production. Nat Immunol 2009; 10: 1089–1095. 37 Zhu J, Yamane H, Paul WE. ...
Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-kappaB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can ...
derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal ...
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
The molecular mechanisms for NF-kappaB signaling transduction and transcription have been the most attractive subjects for both basic research and pharmaceutical industries due to its important roles in both physiological and pathogenesis, particularly the close association of dysregulated NF-kappaB with tumo...
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