Solt L, May M (2008) The IκB kinase complex: master regulator of NF-κB signaling. Immunol Res 42:3–18Solt LA, May MJ: The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res 2008, 42 (1–3) : 3–18....
研究 1.IκBα 在激活NF-κB 信号通路中的作用:当 同时发现,IκBα 基因缺陷小鼠皮肤基底细胞层发育 各种刺激因子(如脂多糖、病毒蛋白、氧自由基、 差,出现鳞片及腐肉,皮肤切片中非炎症性粒细胞 细胞因子)刺激细胞时,级联信号迅速激活IκB 激 明显增多,骨髓及脾脏中性粒前体细胞从出生后2 d 酶(IκB kinase,...
应用免疫组化SP法检测石蜡包埋组织中LMP-1和NF-κB蛋白的阳性率,用DNA末端标记技术(TUNEL)研究细胞凋亡指数(AI),比较其在实验组和对照组中的差异,分析三者的相互关系,讨论其意义。 2. NF-κB, a collective name of dimeric transcription factors, is composed of members of the Rel family proteins that reco...
NF-kappaB signaling has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. However, the cellular and molecular activity of NF-kappaB signaling within the nervous system remains to be clearly defined. Here, we show that the NF-kappaB and IkappaB homologs Dorsal and Cactu...
1、一種新型一種新型 IkappaB Kinase 抑制劑抑制劑 Zerumbone 抑制前發炎物質生成之機轉探討抑制前發炎物質生成之機轉探討n一、 本論文主要探討亞熱帶生薑的倍半帖成分Zerumbone抑制人類肺臟上皮細胞(A549)受interleukin-1beta(IL-1b)引發之cyclooxygenase-2(COX-2)表現及IL-6、IL-8釋放之機制研究。n二、 細胞...
TPCA-1 是一种有效,选择性的 IKK-2 抑制剂,IC50 值为 17.9 nM。TPCA-1 也是STAT3 磷酸化、DNA结合以及反式激活的有效抑制剂。 图1.TPCA-1 化学结构 TPCA-1 基础信息 中文名:5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺;IkappaB 激酶抑制剂;TPCA-1;IkappaB 激酶抑制剂 ...
S7736MLN120BMLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive inhibitor ofIkappaB kinase beta (IKKβ)with an IC50 of 45 nM for recombinant IKKβ. MLN120B does not inhibit other IKK isoforms at IC50 below 50 μM. ...
产品别名: IKKi/IKKe (phospho Ser172); p-IKKi(Ser172); p-IKKe(Ser172); IKKi/IKKe; I kappa B kinase epsilon; IkBKE; IKBKE protein; IKK E; IKK i; IKK-i; IKK related kinase epsilon; IKKE; IKK-E; IKKepsilon; IKKI; Inducible I kappa B kinase; inducible IkappaB kinase; Inhibitor of...
kappa B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor; TCF16; CHUK1; Conserved Helix Loop Helix Ubiquitous Kinase; Conserved helix loop ubiquitous kinase; I Kappa B Kinase 1; IkappaB kinase; IKKA_...
The IkappaB kinase (IKK) complex, composed of two catalytic subunits (IKKalpha and IKKbeta) and a regulatory subunit (IKKgamma), is the key enzyme in activ... BS Miller,E Zandi - 《Journal of Biological Chemistry》 被引量: 1229发表: 2001年 The IkB kinase comple...