Appropriate subcellular localization is crucial for regulation of NF-kappaB function. Herein, we show that latent NF-kappaB complexes can enter and exit the nucleus in preinduction states. The nuclear export inhibitor leptomycin B (LMB) sequestered NF-kappaB/IkappaBalpha complexes in the nucleus. ...
In "frestimate(modelname,op,io,in)", the linearization I/O io(1) seems to be a non-double signal. All input and output IOs are required to be on double signals. this happens when i try to tune the pitch or roll PIDs. i got the model from...
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Signal-transducing function of Na^+ , K^- -ATPase is essential for ouabain's effect on [Ca^2+], in rat cardiac myocytes[J]. Am J Physiol Heart Circ Physiol, 2001, 281: H1899-H1907.Tian J,Gong X,Xie Z.Signal-transducing function of Na+,K+-ATPase is essential for ouabain′s ...
The aim of this phase I study is to evaluate, for the first time, the safety and efficacy of sintilimab in pediatric patients diagnosed with advanced or recurrent malignancies. During the dose escalation phase, patients received a single intravenous infu
Furthermore, 5-HT has been demonstrated to up-regulate transforming growth factor (TGF)-β in mesangial cells via G-protein signal transduction. We investigated the hypothesis that increased exposure of heart valve interstitial cells to 5-HT may result in increased TGF-β1 expression and activity...
Here, we provide evidence that NFκB pathway inhibition via pevonedistat targets malignant cells in MPN patient samples as well as in MPN and patient-derived xenograft mouse models that are nonredundant with ruxolitinib. Colony forming assays revealed preferential inhibition of MF colony growth ...
Based on these data, we conclude that in NTHI 86-028NP, RbsB is a LuxS/AI-2 regulated protein that is required for uptake of and response to AI-2. 展开 关键词: amplified fragment length polymorphism diversity Galega NFR5 NORK Rhizobium galegae DOI: 10.1111/j.1365-2958.2011.07831.x ...
We have shown previously that metabotropic glutamate receptors with group I-like pharmacology couple to N-type and P/Q-type calcium channels in acutely isolated cortical neurons using G proteins most likely belonging to the Gi/Go subclass. To better understand the potential mechanisms forming the ba...
Delay locked loop circuit, digital predistortion type transmitter using same, and wireless base station Disclosed are a delay locked loop circuit capable of accurately extracting nonlinear distortion superimposed on an output of a digital predistortion type transmitter, the digital predistortion type ...