ACY-1215 exhibits anti-inflammatory and chondroprotective effects in human osteoarthritis chondrocytes via inhibition of STAT3 and NF-kappaB signaling pathways. Biomed. Pharmacother. 109, 2464–2471 (2019). Article CAS PubMed Google Scholar Pandey, U. B. et al. HDAC6 rescues neurodegeneration and...
NF-kappaB Transcription Factor Introduction CD95 (also termed APO-1, Fas, tumor necrosis factor receptor superfamily member 6, or TNFRSF6) is a member of the death receptor family, a subfamily of the tumor necrosis factor receptor superfamily. Binding to Fas by its physiological ligand, FasL,...
signaling and elucidate the network response. We identify two first-in-class small molecules that inhibit the NF-κB signaling pathway by preventing the maturation of a rate-limiting multiprotein complex necessary for IKK activation. Our findings suggest that a network-centric drug discovery approach ...
Figure 1. Pevonedistat suppresses TNFα-mediated NFκB signaling in MPNs. (A) Cell viability curve of JAK2 V617F mutant HEL cells treated with increasing concentrations of pevonedistat and ruxolitinib. Cells were treated for 72 hours and viability was normalized to the control treatment. Data...
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007;13(1):70–7. Article PubMed CAS Google Scholar Weng AP, Ferrando AA, Lee W, JPt M, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in ...
Narayanan, et al, Evidence For Differential Functions of the P50 and P65 Subunits of NF-Kappab With a Cell Adhesion Model, Mol. Cell Biol. 13 3802-3810 (1993). Sokoloski, et al. Antisense Oligonucleotides to the P65 Subunit of NF-Kappa-B Block CD11B Expression And Alter Adhesion Properti...
Infection of intestinal epithelial cells by pathogenic Salmonella leads to activation of signaling cascades that ultimately initiate the proinflammatory gene program. The transcription factor NF-κB is a key regulator/activator of this gene program and i
NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain. Front Mol Neurosci 8, 69, doi: 10.3389/fnmol.2015.00069 (2015). 26. Konig, H. G. et al. Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-kappaB signaling in neurons. J ...
et al. Inflammatory cytokines regulate endothelial cell survival and tissue repair functions via NF-kappaB signaling. J. Inflamm. Res. 4, 127–138 (2011). CAS PubMed PubMed Central Google Scholar Aurora, A. B. et al. NF-kappaB balances vascular regression and angiogenesis via chromatin ...
In conclusion, we demonstrate that p65/NF-κB controls ankyrin-G levels via a negative feedback loop, thereby linking NF-κB signaling with neuronal polarity and axonal plasticity. Constitutive NF-κB activity may help to maintain ankyrin-G expression levels in differentiated neurons, while sequestrat...