近日,中山大学附属第三医院心血管内科研究团队在国际经典权威期刊Antioxidants and Redox Signaling上发表了题为“Lipotoxicity induces cardiomyocyte ferroptosis via activating the STING pathway”的研究论文,该研究通过体内外实验提供了铁死亡参与...
2022年10月,瑞金医院胸外科团队在国际知名学术期刊《Signal Transduction and Targeted Therapy》在线发表题为“Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials”——肺鳞癌信号传导通路和靶向治疗:机制和临床研究的综述论文。 瑞金医院胸外科李鹤成教授、上海市免...
Feske and colleagues show how STIM- and ORAI-dependent calcium activation of NFAT plus IFN–STAT1 signaling activates T-bet expression independently of IL-12 stimulation. This NFAT–STAT1 activation pathway is required for TH1 cell differentiation and protection against viral infections when IL-12 is...
Cancer cells can activate diverse signaling pathways to evade the cytotoxic action of drugs. We created and screened a library of barcoded pathway-activating mutant complementary DNAs to identify those that enhanced the survival of cancer cells in the presence of 13 clinically relevant, targeted ther...
Cisplatin toxicity is counteracted by the activation of the p38/ATF-7 signaling pathway in post-mitoticC. elegans In contrast to mammalian cells, C. elegans models can be useful because of cells being post-mitotic in adults. Here the authors show activation of the p38 pathway in cisplatin res...
signaling in response to stress signals. Black arrowsindicate activation whereas red arrows indicate inhibition.> Tarik Regad教授认为,使用小分子抑制剂和抗体靶向这些通路的各个成分在治疗GBM方面目前已经取得了进展,因此,联合多种药物靶向多种信号传导通路的多个要素可能更有利于治疗GBM。肿瘤细胞是异质性的,更显得...
Ca, cAMP & Lipid Signaling Protein Kinase C Signaling Phospholipase Signaling Cell Cycle and Checkpoint Control G1/S Checkpoint G2M/DNA Damage Checkpoint DNA Damage Jak/Stat Pathway IL-6 Receptor Signaling NF-κB Signaling NF-κB Signaling Toll-Like Receptor Signaling TGF-βSignaling Neuroscience ...
signaling in response to stress signals. Black arrowsindicate activation whereas red arrows indicate inhibition.> Tarik Regad教授认为,使用小分子抑制剂和抗体靶向这些通路的各个成分在治疗GBM方面目前已经取得了进展,因此,联合多种药物靶向多种信号传导通路的多个要素可能更有利于治疗GBM。肿瘤细胞是异质性的,更显得...
signaling cascade includes receptors to receive signals, kinases (serine/threonine/tyrosine) that phosphorylate proteins, adaptor proteins that bring kinases and substrates together, and transcription factors that alter gene expression as a response to stimuli. Another signaling pathway regulates ...
Volume: 27, P: 2476-2486 MIMIC-BP: A curated dataset for blood pressure estimation Ivandro Sanches Victor V. Gomes Otávio A. B. Penatti ResearchOpen Access15 Nov 2024Scientific Data Volume: 11, P: 1233 SignalingProfiler2.0 a network-based approach to bridge multi-omics data to phenotypic ...